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Tumor necrosis factor- α, adiponectin and their ratio in gestational diabetes mellitus

BACKGROUND: It has been suggested that inflammation might be implicated in the gestational diabetes mellitus (GDM) complications, including insulin resistance. The aims of the current study were to explore maternal circulating values of TNF-α, adiponectin and the adiponectin/TNF-α ratio in women wit...

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Autores principales: Khosrowbeygi, Ali, Rezvanfar, Mohammad Reza, Ahmadvand, Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771364/
https://www.ncbi.nlm.nih.gov/pubmed/29387323
http://dx.doi.org/10.22088/cjim.9.1.71
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author Khosrowbeygi, Ali
Rezvanfar, Mohammad Reza
Ahmadvand, Hassan
author_facet Khosrowbeygi, Ali
Rezvanfar, Mohammad Reza
Ahmadvand, Hassan
author_sort Khosrowbeygi, Ali
collection PubMed
description BACKGROUND: It has been suggested that inflammation might be implicated in the gestational diabetes mellitus (GDM) complications, including insulin resistance. The aims of the current study were to explore maternal circulating values of TNF-α, adiponectin and the adiponectin/TNF-α ratio in women with GDM compared with normal pregnancy and their relationships with metabolic syndrome biomarkers. METHODS: Forty women with GDM and 40 normal pregnant women were included in the study. Commercially available enzyme-linked immunosorbent assay methods were used to measure serum levels of TNF-α and total adiponectin. RESULTS: Women with GDM had higher values of TNF-α (225.08±27.35 vs 115.68±12.64 pg/ml, p<0.001) and lower values of adiponectin (4.50±0.38 vs 6.37±0.59 µg/ml, p=0.003) and the adiponectin/TNF-α ratio (4.31±0.05 vs 4.80±0.07, P<0.001) than normal pregnant women. The adiponectin/TNF-α ratio showed negative correlations with insulin resistance (r=-0.68, p<0.001) and triglyceride (r=-0.39, p=0.014) and a positive correlation with insulin sensitivity (r=0.69, p<0.001). Multiple linear regression analysis showed that values of the adiponectin /TNF-α ratio were independently associated with insulin resistance. Binary logistic regression analysis showed that GDM was negatively associated with adiponectin /TNF-α ratio. CONCLUSIONS: In summary, the adiponectin/TNF-α ratio decreased significantly in GDM compared with normal pregnancy. The ratio might be an informative biomarker for assessment of pregnant women at high risk of insulin resistance and dyslipidemia and for diagnosis and therapeutic monitoring aims in GDM.
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spelling pubmed-57713642018-01-31 Tumor necrosis factor- α, adiponectin and their ratio in gestational diabetes mellitus Khosrowbeygi, Ali Rezvanfar, Mohammad Reza Ahmadvand, Hassan Caspian J Intern Med Original Article BACKGROUND: It has been suggested that inflammation might be implicated in the gestational diabetes mellitus (GDM) complications, including insulin resistance. The aims of the current study were to explore maternal circulating values of TNF-α, adiponectin and the adiponectin/TNF-α ratio in women with GDM compared with normal pregnancy and their relationships with metabolic syndrome biomarkers. METHODS: Forty women with GDM and 40 normal pregnant women were included in the study. Commercially available enzyme-linked immunosorbent assay methods were used to measure serum levels of TNF-α and total adiponectin. RESULTS: Women with GDM had higher values of TNF-α (225.08±27.35 vs 115.68±12.64 pg/ml, p<0.001) and lower values of adiponectin (4.50±0.38 vs 6.37±0.59 µg/ml, p=0.003) and the adiponectin/TNF-α ratio (4.31±0.05 vs 4.80±0.07, P<0.001) than normal pregnant women. The adiponectin/TNF-α ratio showed negative correlations with insulin resistance (r=-0.68, p<0.001) and triglyceride (r=-0.39, p=0.014) and a positive correlation with insulin sensitivity (r=0.69, p<0.001). Multiple linear regression analysis showed that values of the adiponectin /TNF-α ratio were independently associated with insulin resistance. Binary logistic regression analysis showed that GDM was negatively associated with adiponectin /TNF-α ratio. CONCLUSIONS: In summary, the adiponectin/TNF-α ratio decreased significantly in GDM compared with normal pregnancy. The ratio might be an informative biomarker for assessment of pregnant women at high risk of insulin resistance and dyslipidemia and for diagnosis and therapeutic monitoring aims in GDM. Babol University of Medical Sciences 2018 /pmc/articles/PMC5771364/ /pubmed/29387323 http://dx.doi.org/10.22088/cjim.9.1.71 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Khosrowbeygi, Ali
Rezvanfar, Mohammad Reza
Ahmadvand, Hassan
Tumor necrosis factor- α, adiponectin and their ratio in gestational diabetes mellitus
title Tumor necrosis factor- α, adiponectin and their ratio in gestational diabetes mellitus
title_full Tumor necrosis factor- α, adiponectin and their ratio in gestational diabetes mellitus
title_fullStr Tumor necrosis factor- α, adiponectin and their ratio in gestational diabetes mellitus
title_full_unstemmed Tumor necrosis factor- α, adiponectin and their ratio in gestational diabetes mellitus
title_short Tumor necrosis factor- α, adiponectin and their ratio in gestational diabetes mellitus
title_sort tumor necrosis factor- α, adiponectin and their ratio in gestational diabetes mellitus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771364/
https://www.ncbi.nlm.nih.gov/pubmed/29387323
http://dx.doi.org/10.22088/cjim.9.1.71
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