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The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy

BACKGROUND: Sleep and epilepsy are mutually related in a complex, bidirectional manner. However, our under-standing of this relationship remains unclear. RESULTS: The literatures of the neurobiological basis of the interactions between sleep and epilepsy indicate that non rapid eye movement sleep an...

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Autores principales: Wang, Yi-Qun, Zhang, Meng-Qi, Li, Rui, Qu, Wei-Min, Huang, Zhi-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771383/
https://www.ncbi.nlm.nih.gov/pubmed/28486925
http://dx.doi.org/10.2174/1570159X15666170509101237
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author Wang, Yi-Qun
Zhang, Meng-Qi
Li, Rui
Qu, Wei-Min
Huang, Zhi-Li
author_facet Wang, Yi-Qun
Zhang, Meng-Qi
Li, Rui
Qu, Wei-Min
Huang, Zhi-Li
author_sort Wang, Yi-Qun
collection PubMed
description BACKGROUND: Sleep and epilepsy are mutually related in a complex, bidirectional manner. However, our under-standing of this relationship remains unclear. RESULTS: The literatures of the neurobiological basis of the interactions between sleep and epilepsy indicate that non rapid eye movement sleep and idiopathic generalized epilepsy share the same thalamocortical networks. Most of neurotransmitters and neuromodulators such as adenosine, melatonin, prostaglandin D2, serotonin, and histamine are found to regulate the sleep-wake behavior and also considered to have antiepilepsy effects; antiepileptic drugs, in turn, also have effects on sleep. Fur-thermore, many drugs that regulate the sleep-wake cycle can also serve as potential antiseizure agents. The nonpharmacologi-cal management of epilepsy including ketogenic diet, epilepsy surgery, neurostimulation can also influence sleep. CONCLUSION: In this paper, we address the issues involved in these phenomena and also discuss the various therapies used to modify them.
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spelling pubmed-57713832018-07-01 The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy Wang, Yi-Qun Zhang, Meng-Qi Li, Rui Qu, Wei-Min Huang, Zhi-Li Curr Neuropharmacol Article BACKGROUND: Sleep and epilepsy are mutually related in a complex, bidirectional manner. However, our under-standing of this relationship remains unclear. RESULTS: The literatures of the neurobiological basis of the interactions between sleep and epilepsy indicate that non rapid eye movement sleep and idiopathic generalized epilepsy share the same thalamocortical networks. Most of neurotransmitters and neuromodulators such as adenosine, melatonin, prostaglandin D2, serotonin, and histamine are found to regulate the sleep-wake behavior and also considered to have antiepilepsy effects; antiepileptic drugs, in turn, also have effects on sleep. Fur-thermore, many drugs that regulate the sleep-wake cycle can also serve as potential antiseizure agents. The nonpharmacologi-cal management of epilepsy including ketogenic diet, epilepsy surgery, neurostimulation can also influence sleep. CONCLUSION: In this paper, we address the issues involved in these phenomena and also discuss the various therapies used to modify them. Bentham Science Publishers 2018-01 2018-01 /pmc/articles/PMC5771383/ /pubmed/28486925 http://dx.doi.org/10.2174/1570159X15666170509101237 Text en © 2018 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Wang, Yi-Qun
Zhang, Meng-Qi
Li, Rui
Qu, Wei-Min
Huang, Zhi-Li
The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy
title The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy
title_full The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy
title_fullStr The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy
title_full_unstemmed The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy
title_short The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy
title_sort mutual interaction between sleep and epilepsy on the neurobiological basis and therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771383/
https://www.ncbi.nlm.nih.gov/pubmed/28486925
http://dx.doi.org/10.2174/1570159X15666170509101237
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