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The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy
BACKGROUND: Sleep and epilepsy are mutually related in a complex, bidirectional manner. However, our under-standing of this relationship remains unclear. RESULTS: The literatures of the neurobiological basis of the interactions between sleep and epilepsy indicate that non rapid eye movement sleep an...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771383/ https://www.ncbi.nlm.nih.gov/pubmed/28486925 http://dx.doi.org/10.2174/1570159X15666170509101237 |
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author | Wang, Yi-Qun Zhang, Meng-Qi Li, Rui Qu, Wei-Min Huang, Zhi-Li |
author_facet | Wang, Yi-Qun Zhang, Meng-Qi Li, Rui Qu, Wei-Min Huang, Zhi-Li |
author_sort | Wang, Yi-Qun |
collection | PubMed |
description | BACKGROUND: Sleep and epilepsy are mutually related in a complex, bidirectional manner. However, our under-standing of this relationship remains unclear. RESULTS: The literatures of the neurobiological basis of the interactions between sleep and epilepsy indicate that non rapid eye movement sleep and idiopathic generalized epilepsy share the same thalamocortical networks. Most of neurotransmitters and neuromodulators such as adenosine, melatonin, prostaglandin D2, serotonin, and histamine are found to regulate the sleep-wake behavior and also considered to have antiepilepsy effects; antiepileptic drugs, in turn, also have effects on sleep. Fur-thermore, many drugs that regulate the sleep-wake cycle can also serve as potential antiseizure agents. The nonpharmacologi-cal management of epilepsy including ketogenic diet, epilepsy surgery, neurostimulation can also influence sleep. CONCLUSION: In this paper, we address the issues involved in these phenomena and also discuss the various therapies used to modify them. |
format | Online Article Text |
id | pubmed-5771383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-57713832018-07-01 The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy Wang, Yi-Qun Zhang, Meng-Qi Li, Rui Qu, Wei-Min Huang, Zhi-Li Curr Neuropharmacol Article BACKGROUND: Sleep and epilepsy are mutually related in a complex, bidirectional manner. However, our under-standing of this relationship remains unclear. RESULTS: The literatures of the neurobiological basis of the interactions between sleep and epilepsy indicate that non rapid eye movement sleep and idiopathic generalized epilepsy share the same thalamocortical networks. Most of neurotransmitters and neuromodulators such as adenosine, melatonin, prostaglandin D2, serotonin, and histamine are found to regulate the sleep-wake behavior and also considered to have antiepilepsy effects; antiepileptic drugs, in turn, also have effects on sleep. Fur-thermore, many drugs that regulate the sleep-wake cycle can also serve as potential antiseizure agents. The nonpharmacologi-cal management of epilepsy including ketogenic diet, epilepsy surgery, neurostimulation can also influence sleep. CONCLUSION: In this paper, we address the issues involved in these phenomena and also discuss the various therapies used to modify them. Bentham Science Publishers 2018-01 2018-01 /pmc/articles/PMC5771383/ /pubmed/28486925 http://dx.doi.org/10.2174/1570159X15666170509101237 Text en © 2018 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Wang, Yi-Qun Zhang, Meng-Qi Li, Rui Qu, Wei-Min Huang, Zhi-Li The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy |
title | The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy |
title_full | The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy |
title_fullStr | The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy |
title_full_unstemmed | The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy |
title_short | The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy |
title_sort | mutual interaction between sleep and epilepsy on the neurobiological basis and therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771383/ https://www.ncbi.nlm.nih.gov/pubmed/28486925 http://dx.doi.org/10.2174/1570159X15666170509101237 |
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