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The Anticonvulsant Effects of Ketogenic Diet on Epileptic Seizures and Potential Mechanisms
BACKGROUND: Epilepsy is a syndrome of brain dysfunction induced by the aberrant excitability of certain neurons. Despite advances in surgical technique and anti-epileptic drug in recent years, recurrent epileptic seizures remain intractable and lead to a serious morbidity in the world. The ketogenic...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771386/ https://www.ncbi.nlm.nih.gov/pubmed/28521671 http://dx.doi.org/10.2174/1570159X15666170517153509 |
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author | Zhang, Yifan Xu, Jingwei Zhang, Kun Yang, Wei Li, Bingjin |
author_facet | Zhang, Yifan Xu, Jingwei Zhang, Kun Yang, Wei Li, Bingjin |
author_sort | Zhang, Yifan |
collection | PubMed |
description | BACKGROUND: Epilepsy is a syndrome of brain dysfunction induced by the aberrant excitability of certain neurons. Despite advances in surgical technique and anti-epileptic drug in recent years, recurrent epileptic seizures remain intractable and lead to a serious morbidity in the world. The ketogenic diet refers to a high-fat, low-carbohydrate and adequate-protein diet.Currently, its beneficial effects on epileptic seizure reduction have been well established. However, the detailed mechanisms underlying the anti-epileptic effects of ketogenic diet are still poorly understood. In this article, the possible roles of ketogenic diet on epilepsy were discussed. METHODS: Data was obtained from the websites including Web of Science, Medline, Pubmed,Scopus, based on these keywords: “Ketogenic diet” and “epilepsy”. RESULTS: As shown in both clinical and basic studies, the therapeutic effects of ketogenic diet might involve neuronal metabolism, neurotransmitter function, neuronal membrane potential and neuron protection against ROS. CONCLUSION: In this review, we systematically reviewed the effects and possible mechanisms of ketogenic diet on epilepsy, which may optimize the therapeutic strategies against epilepsy. |
format | Online Article Text |
id | pubmed-5771386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-57713862018-07-01 The Anticonvulsant Effects of Ketogenic Diet on Epileptic Seizures and Potential Mechanisms Zhang, Yifan Xu, Jingwei Zhang, Kun Yang, Wei Li, Bingjin Curr Neuropharmacol Article BACKGROUND: Epilepsy is a syndrome of brain dysfunction induced by the aberrant excitability of certain neurons. Despite advances in surgical technique and anti-epileptic drug in recent years, recurrent epileptic seizures remain intractable and lead to a serious morbidity in the world. The ketogenic diet refers to a high-fat, low-carbohydrate and adequate-protein diet.Currently, its beneficial effects on epileptic seizure reduction have been well established. However, the detailed mechanisms underlying the anti-epileptic effects of ketogenic diet are still poorly understood. In this article, the possible roles of ketogenic diet on epilepsy were discussed. METHODS: Data was obtained from the websites including Web of Science, Medline, Pubmed,Scopus, based on these keywords: “Ketogenic diet” and “epilepsy”. RESULTS: As shown in both clinical and basic studies, the therapeutic effects of ketogenic diet might involve neuronal metabolism, neurotransmitter function, neuronal membrane potential and neuron protection against ROS. CONCLUSION: In this review, we systematically reviewed the effects and possible mechanisms of ketogenic diet on epilepsy, which may optimize the therapeutic strategies against epilepsy. Bentham Science Publishers 2018-01 2018-01 /pmc/articles/PMC5771386/ /pubmed/28521671 http://dx.doi.org/10.2174/1570159X15666170517153509 Text en © 2018 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Zhang, Yifan Xu, Jingwei Zhang, Kun Yang, Wei Li, Bingjin The Anticonvulsant Effects of Ketogenic Diet on Epileptic Seizures and Potential Mechanisms |
title | The Anticonvulsant Effects of Ketogenic Diet on Epileptic Seizures and Potential Mechanisms |
title_full | The Anticonvulsant Effects of Ketogenic Diet on Epileptic Seizures and Potential Mechanisms |
title_fullStr | The Anticonvulsant Effects of Ketogenic Diet on Epileptic Seizures and Potential Mechanisms |
title_full_unstemmed | The Anticonvulsant Effects of Ketogenic Diet on Epileptic Seizures and Potential Mechanisms |
title_short | The Anticonvulsant Effects of Ketogenic Diet on Epileptic Seizures and Potential Mechanisms |
title_sort | anticonvulsant effects of ketogenic diet on epileptic seizures and potential mechanisms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771386/ https://www.ncbi.nlm.nih.gov/pubmed/28521671 http://dx.doi.org/10.2174/1570159X15666170517153509 |
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