Expression of the lux genes in Streptococcus pneumoniae modulates pilus expression and virulence

Bioluminescence has been harnessed for use in bacterial reporter systems and for in vivo imaging of infection in animal models. Strain Xen35, a bioluminescent derivative of Streptococcus pneumoniae serotype 4 strain TIGR4 was previously constructed for use for in vivo imaging of infections in animal...

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Autores principales: Herbert, Jenny A., Mitchell, Andrea M., Ritchie, Ryan, Ma, Jiangtao, Ross-Hutchinson, Kirsty, Mitchell, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771582/
https://www.ncbi.nlm.nih.gov/pubmed/29342160
http://dx.doi.org/10.1371/journal.pone.0189426
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author Herbert, Jenny A.
Mitchell, Andrea M.
Ritchie, Ryan
Ma, Jiangtao
Ross-Hutchinson, Kirsty
Mitchell, Timothy J.
author_facet Herbert, Jenny A.
Mitchell, Andrea M.
Ritchie, Ryan
Ma, Jiangtao
Ross-Hutchinson, Kirsty
Mitchell, Timothy J.
author_sort Herbert, Jenny A.
collection PubMed
description Bioluminescence has been harnessed for use in bacterial reporter systems and for in vivo imaging of infection in animal models. Strain Xen35, a bioluminescent derivative of Streptococcus pneumoniae serotype 4 strain TIGR4 was previously constructed for use for in vivo imaging of infections in animal models. We have shown that strain Xen35 is less virulent than its parent TIGR4 and that this is associated with the expression of the genes for bioluminescence. The expression of the luxA-E genes in the pneumococcus reduces virulence and down regulates the expression of the pneumococcal pilus.
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spelling pubmed-57715822018-01-23 Expression of the lux genes in Streptococcus pneumoniae modulates pilus expression and virulence Herbert, Jenny A. Mitchell, Andrea M. Ritchie, Ryan Ma, Jiangtao Ross-Hutchinson, Kirsty Mitchell, Timothy J. PLoS One Research Article Bioluminescence has been harnessed for use in bacterial reporter systems and for in vivo imaging of infection in animal models. Strain Xen35, a bioluminescent derivative of Streptococcus pneumoniae serotype 4 strain TIGR4 was previously constructed for use for in vivo imaging of infections in animal models. We have shown that strain Xen35 is less virulent than its parent TIGR4 and that this is associated with the expression of the genes for bioluminescence. The expression of the luxA-E genes in the pneumococcus reduces virulence and down regulates the expression of the pneumococcal pilus. Public Library of Science 2018-01-17 /pmc/articles/PMC5771582/ /pubmed/29342160 http://dx.doi.org/10.1371/journal.pone.0189426 Text en © 2018 Herbert et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Herbert, Jenny A.
Mitchell, Andrea M.
Ritchie, Ryan
Ma, Jiangtao
Ross-Hutchinson, Kirsty
Mitchell, Timothy J.
Expression of the lux genes in Streptococcus pneumoniae modulates pilus expression and virulence
title Expression of the lux genes in Streptococcus pneumoniae modulates pilus expression and virulence
title_full Expression of the lux genes in Streptococcus pneumoniae modulates pilus expression and virulence
title_fullStr Expression of the lux genes in Streptococcus pneumoniae modulates pilus expression and virulence
title_full_unstemmed Expression of the lux genes in Streptococcus pneumoniae modulates pilus expression and virulence
title_short Expression of the lux genes in Streptococcus pneumoniae modulates pilus expression and virulence
title_sort expression of the lux genes in streptococcus pneumoniae modulates pilus expression and virulence
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771582/
https://www.ncbi.nlm.nih.gov/pubmed/29342160
http://dx.doi.org/10.1371/journal.pone.0189426
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