Functional interrogation of Plasmodium genus metabolism identifies species- and stage-specific differences in nutrient essentiality and drug targeting

Several antimalarial drugs exist, but differences between life cycle stages among malaria species pose challenges for developing more effective therapies. To understand the diversity among stages and species, we reconstructed genome-scale metabolic models (GeMMs) of metabolism for five life cycle st...

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Detalles Bibliográficos
Autores principales: Abdel-Haleem, Alyaa M., Hefzi, Hooman, Mineta, Katsuhiko, Gao, Xin, Gojobori, Takashi, Palsson, Bernhard O., Lewis, Nathan E., Jamshidi, Neema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771636/
https://www.ncbi.nlm.nih.gov/pubmed/29300748
http://dx.doi.org/10.1371/journal.pcbi.1005895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771636/
https://www.ncbi.nlm.nih.gov/pubmed/29300748
http://dx.doi.org/10.1371/journal.pcbi.1005895

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