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Osteoporosis in Patients with Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome
BACKGROUND: Osteoporosis is a common disease that occurs comorbidly in patients with chronic inflammatory airway diseases, including asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap syndrome (ACOS). However, the prevalence of osteoporosis in patients with ACOS has not wi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Tuberculosis and Respiratory Diseases
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771749/ https://www.ncbi.nlm.nih.gov/pubmed/29256216 http://dx.doi.org/10.4046/trd.2017.0066 |
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author | Oh, Jee Youn Lee, Young Seok Min, Kyung Hoon Lee, Sung Yong Shim, Jae Jeong Kang, Kyung Ho Hur, Gyu Young |
author_facet | Oh, Jee Youn Lee, Young Seok Min, Kyung Hoon Lee, Sung Yong Shim, Jae Jeong Kang, Kyung Ho Hur, Gyu Young |
author_sort | Oh, Jee Youn |
collection | PubMed |
description | BACKGROUND: Osteoporosis is a common disease that occurs comorbidly in patients with chronic inflammatory airway diseases, including asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap syndrome (ACOS). However, the prevalence of osteoporosis in patients with ACOS has not widely been evaluated. Therefore, we investigated the prevalence of osteoporosis and its relationship with the clinical parameters of patients with asthma, COPD, and ACOS. METHODS: This was a retrospective, cross-sectional study. Bone mineral density (BMD), lung function tests, and disease status evaluations were conducted. RESULTS: A total of 321 patients were enrolled: 138 with asthma, 46 with ACOS, and 137 with COPD. One hundred and ninety-three patients (60.1%) were diagnosed with osteoporosis (53.6% of asthma, 65.2% of ACOS, and 65.0% of COPD). Patients with ACOS showed a significantly lower BMD and T-score than did those with asthma. In addition to age, sex, and body mass index (BMI), which were previously reported to be associated with BMD, BMD also had a negative correlation with the diagnosis of ACOS, as compared to a diagnosis of asthma, after adjusting for age, sex, BMI, smoking, and inhaled corticosteroid use (p=0.001). Among those patients with COPD and ACOS, BMD was negatively associated with the COPD Assessment Test (CAT) after adjustment (p<0.001). Inhaled corticosteroid was not associated with the prevalence of osteoporosis and BMD. CONCLUSION: Patients with ACOS, particularly aged and lean women, should be more carefully monitored for osteoporosis as compared to patients with asthma. |
format | Online Article Text |
id | pubmed-5771749 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Korean Academy of Tuberculosis and Respiratory Diseases |
record_format | MEDLINE/PubMed |
spelling | pubmed-57717492018-01-21 Osteoporosis in Patients with Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome Oh, Jee Youn Lee, Young Seok Min, Kyung Hoon Lee, Sung Yong Shim, Jae Jeong Kang, Kyung Ho Hur, Gyu Young Tuberc Respir Dis (Seoul) Original Article BACKGROUND: Osteoporosis is a common disease that occurs comorbidly in patients with chronic inflammatory airway diseases, including asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap syndrome (ACOS). However, the prevalence of osteoporosis in patients with ACOS has not widely been evaluated. Therefore, we investigated the prevalence of osteoporosis and its relationship with the clinical parameters of patients with asthma, COPD, and ACOS. METHODS: This was a retrospective, cross-sectional study. Bone mineral density (BMD), lung function tests, and disease status evaluations were conducted. RESULTS: A total of 321 patients were enrolled: 138 with asthma, 46 with ACOS, and 137 with COPD. One hundred and ninety-three patients (60.1%) were diagnosed with osteoporosis (53.6% of asthma, 65.2% of ACOS, and 65.0% of COPD). Patients with ACOS showed a significantly lower BMD and T-score than did those with asthma. In addition to age, sex, and body mass index (BMI), which were previously reported to be associated with BMD, BMD also had a negative correlation with the diagnosis of ACOS, as compared to a diagnosis of asthma, after adjusting for age, sex, BMI, smoking, and inhaled corticosteroid use (p=0.001). Among those patients with COPD and ACOS, BMD was negatively associated with the COPD Assessment Test (CAT) after adjustment (p<0.001). Inhaled corticosteroid was not associated with the prevalence of osteoporosis and BMD. CONCLUSION: Patients with ACOS, particularly aged and lean women, should be more carefully monitored for osteoporosis as compared to patients with asthma. The Korean Academy of Tuberculosis and Respiratory Diseases 2018-01 2017-11-27 /pmc/articles/PMC5771749/ /pubmed/29256216 http://dx.doi.org/10.4046/trd.2017.0066 Text en Copyright©2018. The Korean Academy of Tuberculosis and Respiratory Diseases http://creativecommons.org/licenses/by-nc/4.0/ It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | Original Article Oh, Jee Youn Lee, Young Seok Min, Kyung Hoon Lee, Sung Yong Shim, Jae Jeong Kang, Kyung Ho Hur, Gyu Young Osteoporosis in Patients with Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome |
title | Osteoporosis in Patients with Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome |
title_full | Osteoporosis in Patients with Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome |
title_fullStr | Osteoporosis in Patients with Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome |
title_full_unstemmed | Osteoporosis in Patients with Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome |
title_short | Osteoporosis in Patients with Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome |
title_sort | osteoporosis in patients with asthma–chronic obstructive pulmonary disease overlap syndrome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771749/ https://www.ncbi.nlm.nih.gov/pubmed/29256216 http://dx.doi.org/10.4046/trd.2017.0066 |
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