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The effects of ethyl-2-cyanoacrylate and butyl-2-cyanoacrylate in the process of bone healing in rats. A controlled experimental study()

OBJECTIVE: Synthetic adhesives are used by various medical specialties, especially in surgery; however, studies reporting their use in orthopedic practice are scarce. The aim of this study was to compare the results in using ethyl-2-cyanoacrylate or butyl-2-cyanoacrylate in the treatment of fracture...

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Autores principales: Palacio, Evandro Pereira, Pereira, Gilberto José Cação, Silvares, Paulo Roberto de Almeida, Stasi, Gabriel Guimarães Di, Staut, Caio de Andrade, Sardenberg, Trajano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771781/
https://www.ncbi.nlm.nih.gov/pubmed/29367907
http://dx.doi.org/10.1016/j.rboe.2017.11.010
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author Palacio, Evandro Pereira
Pereira, Gilberto José Cação
Silvares, Paulo Roberto de Almeida
Stasi, Gabriel Guimarães Di
Staut, Caio de Andrade
Sardenberg, Trajano
author_facet Palacio, Evandro Pereira
Pereira, Gilberto José Cação
Silvares, Paulo Roberto de Almeida
Stasi, Gabriel Guimarães Di
Staut, Caio de Andrade
Sardenberg, Trajano
author_sort Palacio, Evandro Pereira
collection PubMed
description OBJECTIVE: Synthetic adhesives are used by various medical specialties, especially in surgery; however, studies reporting their use in orthopedic practice are scarce. The aim of this study was to compare the results in using ethyl-2-cyanoacrylate or butyl-2-cyanoacrylate in the treatment of fractures in rats. METHODS: This was an experimental prospective controlled study in 90 rats, with humerus, femur, and tibia fractures, treated with ethyl-2-cyanoacrylate (SB group; n = 45) or butyl-2-cyanoacrylate (HA group; n = 45). Biomechanical and histomorphometric analyses were performed at three different moments (60, 120, and 180 days); besides a clinical study performed weekly by measurement of the animals body mass. RESULTS: No differences were observed regarding body mass (p = 0.07). In both groups, there were no significant differences regarding maximum load (p = 0.6), yield point strength (p = 0.6), and stiffness coefficient (p = 0.4) of the femurs. The same was observed in tibias for maximum load (p = 0.4), yield point strength (p = 0.7), and stiffness coefficient (p = 0.6). The humerus from both groups had similar bone callus area (p = 0.66). In both groups, there were no statistical differences related to inflammatory cells (p = 0.4), osteoblasts (p = 0.2), and osteoclasts (p = 0.2). CONCLUSION: Ethyl-2-cyanoacrylate was more effective than butyl-2-cyanoacrylate in the treatment of fractures in rats.
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spelling pubmed-57717812018-01-24 The effects of ethyl-2-cyanoacrylate and butyl-2-cyanoacrylate in the process of bone healing in rats. A controlled experimental study() Palacio, Evandro Pereira Pereira, Gilberto José Cação Silvares, Paulo Roberto de Almeida Stasi, Gabriel Guimarães Di Staut, Caio de Andrade Sardenberg, Trajano Rev Bras Ortop Original Article OBJECTIVE: Synthetic adhesives are used by various medical specialties, especially in surgery; however, studies reporting their use in orthopedic practice are scarce. The aim of this study was to compare the results in using ethyl-2-cyanoacrylate or butyl-2-cyanoacrylate in the treatment of fractures in rats. METHODS: This was an experimental prospective controlled study in 90 rats, with humerus, femur, and tibia fractures, treated with ethyl-2-cyanoacrylate (SB group; n = 45) or butyl-2-cyanoacrylate (HA group; n = 45). Biomechanical and histomorphometric analyses were performed at three different moments (60, 120, and 180 days); besides a clinical study performed weekly by measurement of the animals body mass. RESULTS: No differences were observed regarding body mass (p = 0.07). In both groups, there were no significant differences regarding maximum load (p = 0.6), yield point strength (p = 0.6), and stiffness coefficient (p = 0.4) of the femurs. The same was observed in tibias for maximum load (p = 0.4), yield point strength (p = 0.7), and stiffness coefficient (p = 0.6). The humerus from both groups had similar bone callus area (p = 0.66). In both groups, there were no statistical differences related to inflammatory cells (p = 0.4), osteoblasts (p = 0.2), and osteoclasts (p = 0.2). CONCLUSION: Ethyl-2-cyanoacrylate was more effective than butyl-2-cyanoacrylate in the treatment of fractures in rats. Elsevier 2017-12-06 /pmc/articles/PMC5771781/ /pubmed/29367907 http://dx.doi.org/10.1016/j.rboe.2017.11.010 Text en © 2017 Sociedade Brasileira de Ortopedia e Traumatologia. Published by Elsevier Editora Ltda. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Palacio, Evandro Pereira
Pereira, Gilberto José Cação
Silvares, Paulo Roberto de Almeida
Stasi, Gabriel Guimarães Di
Staut, Caio de Andrade
Sardenberg, Trajano
The effects of ethyl-2-cyanoacrylate and butyl-2-cyanoacrylate in the process of bone healing in rats. A controlled experimental study()
title The effects of ethyl-2-cyanoacrylate and butyl-2-cyanoacrylate in the process of bone healing in rats. A controlled experimental study()
title_full The effects of ethyl-2-cyanoacrylate and butyl-2-cyanoacrylate in the process of bone healing in rats. A controlled experimental study()
title_fullStr The effects of ethyl-2-cyanoacrylate and butyl-2-cyanoacrylate in the process of bone healing in rats. A controlled experimental study()
title_full_unstemmed The effects of ethyl-2-cyanoacrylate and butyl-2-cyanoacrylate in the process of bone healing in rats. A controlled experimental study()
title_short The effects of ethyl-2-cyanoacrylate and butyl-2-cyanoacrylate in the process of bone healing in rats. A controlled experimental study()
title_sort effects of ethyl-2-cyanoacrylate and butyl-2-cyanoacrylate in the process of bone healing in rats. a controlled experimental study()
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771781/
https://www.ncbi.nlm.nih.gov/pubmed/29367907
http://dx.doi.org/10.1016/j.rboe.2017.11.010
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