Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes

Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells; however, its function in cardiomyocytes is unknown. Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors, such as the chaperone Hsp90. Here we show that...

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Detalles Bibliográficos
Autores principales: Krysiak, Judith, Unger, Andreas, Beckendorf, Lisa, Hamdani, Nazha, von Frieling-Salewsky, Marion, Redfield, Margaret M., dos Remedios, Cris G., Sheikh, Farah, Gergs, Ulrich, Boknik, Peter, Linke, Wolfgang A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772059/
https://www.ncbi.nlm.nih.gov/pubmed/29343782
http://dx.doi.org/10.1038/s41467-017-02483-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772059/
https://www.ncbi.nlm.nih.gov/pubmed/29343782
http://dx.doi.org/10.1038/s41467-017-02483-3

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