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Design, synthesis, cytotoxicity evaluation and docking studies of 1,2,4-triazine derivatives bearing different arylidene-hydrazinyl moieties as potential mTOR inhibitors

Mammalian target of rapamycin (mTOR) is a phosphoinositide 3-kinase-related protein kinase which controls cell growth and is frequently deregulated in many cancers. Therefore, mTOR inhibitors are used as antineoplastic agents for cancer treatment. In this study, 1,2,4-triazine derivatives containing...

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Detalles Bibliográficos
Autores principales:	Ranjbar, Sara, Edraki, Najmeh, Khoshneviszadeh, Mahsima, Foroumadi, Alireza, Miri, Ramin, Khoshneviszadeh, Mehdi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772076/ https://www.ncbi.nlm.nih.gov/pubmed/29387106 http://dx.doi.org/10.4103/1735-5362.220962

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