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The effects of diurnal intermittent fasting on the wake-promoting neurotransmitter orexin-A

BACKGROUND: Food restriction has been demonstrated to increase the alertness in different species and to increase the levels of the wake-promoting neurotransmitter orexin. We hypothesized that diurnal intermittent fasting (DIF) increases orexin-A levels during fasting. Therefore, we conducted this s...

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Autores principales: Almeneessier, Aljohara S., Alzoghaibi, Mohammed, BaHammam, Abdulrahman A., Ibrahim, Mahmoud G., Olaish, Awad H., Nashwan, Samar Z., BaHammam, Ahmed S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772108/
https://www.ncbi.nlm.nih.gov/pubmed/29387256
http://dx.doi.org/10.4103/atm.ATM_181_17
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author Almeneessier, Aljohara S.
Alzoghaibi, Mohammed
BaHammam, Abdulrahman A.
Ibrahim, Mahmoud G.
Olaish, Awad H.
Nashwan, Samar Z.
BaHammam, Ahmed S.
author_facet Almeneessier, Aljohara S.
Alzoghaibi, Mohammed
BaHammam, Abdulrahman A.
Ibrahim, Mahmoud G.
Olaish, Awad H.
Nashwan, Samar Z.
BaHammam, Ahmed S.
author_sort Almeneessier, Aljohara S.
collection PubMed
description BACKGROUND: Food restriction has been demonstrated to increase the alertness in different species and to increase the levels of the wake-promoting neurotransmitter orexin. We hypothesized that diurnal intermittent fasting (DIF) increases orexin-A levels during fasting. Therefore, we conducted this study to assess the effects of DIF, during the month of Ramadan, on orexin, while controlling for lifestyle changes that may accompany Ramadan such as sleep duration, bedtime and wake time, energy expenditure, light exposure, and food. METHODS: Eight young healthy volunteers (mean age, 25.4 ± 3.5 years) reported to the laboratory on three occasions: (1) 4 weeks before Ramadan while performing DIF for 1 week outside the month of Ramadan (fasting outside Ramadan); (2) 1 week before Ramadan (nonfasting baseline) (BL); and (3) during the 2(nd) week of Ramadan while performing DIF (Ramadan). Plasma levels of orexin-A were measured using an enzyme immunoassay five times at 22:00, 02:00, 04:00, 06:00, and 11:00. Caloric intake, light exposure, and sleep schedule were maintained during the participants’ stays in the laboratory in the three study periods. RESULTS: Orexin-A levels increased in the daytime during fasting and decreased at night compared to BL. The differences in orexin-A levels between DIF and BL were significant at 06:00, 11:00, 22:00, and 02:00. CONCLUSIONS: DIF increases orexin-A levels in the plasma during fasting hours. This finding supports findings from animal studies showing that fasting increases alertness.
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spelling pubmed-57721082018-01-31 The effects of diurnal intermittent fasting on the wake-promoting neurotransmitter orexin-A Almeneessier, Aljohara S. Alzoghaibi, Mohammed BaHammam, Abdulrahman A. Ibrahim, Mahmoud G. Olaish, Awad H. Nashwan, Samar Z. BaHammam, Ahmed S. Ann Thorac Med Original Article BACKGROUND: Food restriction has been demonstrated to increase the alertness in different species and to increase the levels of the wake-promoting neurotransmitter orexin. We hypothesized that diurnal intermittent fasting (DIF) increases orexin-A levels during fasting. Therefore, we conducted this study to assess the effects of DIF, during the month of Ramadan, on orexin, while controlling for lifestyle changes that may accompany Ramadan such as sleep duration, bedtime and wake time, energy expenditure, light exposure, and food. METHODS: Eight young healthy volunteers (mean age, 25.4 ± 3.5 years) reported to the laboratory on three occasions: (1) 4 weeks before Ramadan while performing DIF for 1 week outside the month of Ramadan (fasting outside Ramadan); (2) 1 week before Ramadan (nonfasting baseline) (BL); and (3) during the 2(nd) week of Ramadan while performing DIF (Ramadan). Plasma levels of orexin-A were measured using an enzyme immunoassay five times at 22:00, 02:00, 04:00, 06:00, and 11:00. Caloric intake, light exposure, and sleep schedule were maintained during the participants’ stays in the laboratory in the three study periods. RESULTS: Orexin-A levels increased in the daytime during fasting and decreased at night compared to BL. The differences in orexin-A levels between DIF and BL were significant at 06:00, 11:00, 22:00, and 02:00. CONCLUSIONS: DIF increases orexin-A levels in the plasma during fasting hours. This finding supports findings from animal studies showing that fasting increases alertness. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5772108/ /pubmed/29387256 http://dx.doi.org/10.4103/atm.ATM_181_17 Text en Copyright: © 2018 Annals of Thoracic Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Almeneessier, Aljohara S.
Alzoghaibi, Mohammed
BaHammam, Abdulrahman A.
Ibrahim, Mahmoud G.
Olaish, Awad H.
Nashwan, Samar Z.
BaHammam, Ahmed S.
The effects of diurnal intermittent fasting on the wake-promoting neurotransmitter orexin-A
title The effects of diurnal intermittent fasting on the wake-promoting neurotransmitter orexin-A
title_full The effects of diurnal intermittent fasting on the wake-promoting neurotransmitter orexin-A
title_fullStr The effects of diurnal intermittent fasting on the wake-promoting neurotransmitter orexin-A
title_full_unstemmed The effects of diurnal intermittent fasting on the wake-promoting neurotransmitter orexin-A
title_short The effects of diurnal intermittent fasting on the wake-promoting neurotransmitter orexin-A
title_sort effects of diurnal intermittent fasting on the wake-promoting neurotransmitter orexin-a
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772108/
https://www.ncbi.nlm.nih.gov/pubmed/29387256
http://dx.doi.org/10.4103/atm.ATM_181_17
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