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Molecular imaging of cardiac remodelling after myocardial infarction

Myocardial infarction and subsequent heart failure is a major health burden associated with significant mortality and morbidity in western societies. The ability of cardiac tissue to recover after myocardial infarction is affected by numerous complex cellular and molecular pathways. Unbalance or fai...

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Detalles Bibliográficos
Autores principales: Curley, Daniel, Lavin Plaza, Begoña, Shah, Ajay M., Botnar, René M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772148/
https://www.ncbi.nlm.nih.gov/pubmed/29344827
http://dx.doi.org/10.1007/s00395-018-0668-z
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author Curley, Daniel
Lavin Plaza, Begoña
Shah, Ajay M.
Botnar, René M.
author_facet Curley, Daniel
Lavin Plaza, Begoña
Shah, Ajay M.
Botnar, René M.
author_sort Curley, Daniel
collection PubMed
description Myocardial infarction and subsequent heart failure is a major health burden associated with significant mortality and morbidity in western societies. The ability of cardiac tissue to recover after myocardial infarction is affected by numerous complex cellular and molecular pathways. Unbalance or failure of these pathways can lead to adverse remodelling of the heart and poor prognosis. Current clinical cardiac imaging modalities assess anatomy, perfusion, function, and viability of the myocardium, yet do not offer any insight into the specific molecular pathways involved in the repair process. Novel imaging techniques allow visualisation of these molecular processes and may have significant diagnostic and prognostic values, which could aid clinical management. Single photon-emission tomography, positron-emission tomography, and magnetic resonance imaging are used to visualise various aspects of these molecular processes. Imaging probes are usually attached to radioisotopes or paramagnetic nanoparticles to specifically target biological processes such as: apoptosis, necrosis, inflammation, angiogenesis, and scar formation. Although the results from preclinical studies are promising, translating this work to a clinical environment in a valuable and cost-effective way is extremely challenging. Extensive evaluation evidence of diagnostic and prognostic values in multi-centre clinical trials is still required.
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spelling pubmed-57721482018-01-30 Molecular imaging of cardiac remodelling after myocardial infarction Curley, Daniel Lavin Plaza, Begoña Shah, Ajay M. Botnar, René M. Basic Res Cardiol Review Myocardial infarction and subsequent heart failure is a major health burden associated with significant mortality and morbidity in western societies. The ability of cardiac tissue to recover after myocardial infarction is affected by numerous complex cellular and molecular pathways. Unbalance or failure of these pathways can lead to adverse remodelling of the heart and poor prognosis. Current clinical cardiac imaging modalities assess anatomy, perfusion, function, and viability of the myocardium, yet do not offer any insight into the specific molecular pathways involved in the repair process. Novel imaging techniques allow visualisation of these molecular processes and may have significant diagnostic and prognostic values, which could aid clinical management. Single photon-emission tomography, positron-emission tomography, and magnetic resonance imaging are used to visualise various aspects of these molecular processes. Imaging probes are usually attached to radioisotopes or paramagnetic nanoparticles to specifically target biological processes such as: apoptosis, necrosis, inflammation, angiogenesis, and scar formation. Although the results from preclinical studies are promising, translating this work to a clinical environment in a valuable and cost-effective way is extremely challenging. Extensive evaluation evidence of diagnostic and prognostic values in multi-centre clinical trials is still required. Springer Berlin Heidelberg 2018-01-17 2018 /pmc/articles/PMC5772148/ /pubmed/29344827 http://dx.doi.org/10.1007/s00395-018-0668-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Curley, Daniel
Lavin Plaza, Begoña
Shah, Ajay M.
Botnar, René M.
Molecular imaging of cardiac remodelling after myocardial infarction
title Molecular imaging of cardiac remodelling after myocardial infarction
title_full Molecular imaging of cardiac remodelling after myocardial infarction
title_fullStr Molecular imaging of cardiac remodelling after myocardial infarction
title_full_unstemmed Molecular imaging of cardiac remodelling after myocardial infarction
title_short Molecular imaging of cardiac remodelling after myocardial infarction
title_sort molecular imaging of cardiac remodelling after myocardial infarction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772148/
https://www.ncbi.nlm.nih.gov/pubmed/29344827
http://dx.doi.org/10.1007/s00395-018-0668-z
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