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Altered power spectral density in the resting-state sensorimotor network in patients with myotonic dystrophy type 1

Myotonic dystrophy type 1 (DM1) is a multisystemic disease that involves the brain with several neurological symptoms. Although there were few imaging studies on DM1, no studies have investigated functional alterations in the sensorimotor network at rest in patients with DM1. In the current study, a...

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Autores principales: Park, Jin-Sung, Seo, Jeehye, Cha, Hyunsil, Song, Hui-Jin, Lee, Sang-Hoon, Jang, Kyung Eun, Lee, Hui Joong, Park, Juyoung, Lee, Ho-Won, Chang, Yongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772436/
https://www.ncbi.nlm.nih.gov/pubmed/29343751
http://dx.doi.org/10.1038/s41598-018-19217-0
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author Park, Jin-Sung
Seo, Jeehye
Cha, Hyunsil
Song, Hui-Jin
Lee, Sang-Hoon
Jang, Kyung Eun
Lee, Hui Joong
Park, Juyoung
Lee, Ho-Won
Chang, Yongmin
author_facet Park, Jin-Sung
Seo, Jeehye
Cha, Hyunsil
Song, Hui-Jin
Lee, Sang-Hoon
Jang, Kyung Eun
Lee, Hui Joong
Park, Juyoung
Lee, Ho-Won
Chang, Yongmin
author_sort Park, Jin-Sung
collection PubMed
description Myotonic dystrophy type 1 (DM1) is a multisystemic disease that involves the brain with several neurological symptoms. Although there were few imaging studies on DM1, no studies have investigated functional alterations in the sensorimotor network at rest in patients with DM1. In the current study, a power spectral density (PSD) analysis of resting-state fMRI data was performed to assess possible alteration in spontaneous neural activity of the sensorimotor network in patients with DM1. Compared to healthy controls, patients with DM1 showed higher PSD responses in the orbitofrontal cortex, parahippocampus and basal ganglia (corrected P < 0.05). Patients with DM1 showed higher PSD responses in white matter structures associated with motor function (corrected P < 0.05). Furthermore, correlation analysis indicated that the brain regions showing PSD differences were correlated with measures of motor performance (P < 0.05). In gray matter, our findings suggest that motor disability in DM1 is not an isolated deterioration of the motor power but a multimodal dysfunction that also involves the visual system. In addition, the widespread PSD alteration in white matter structures suggest that motor deficits in DM1 involve motor movement structures as well as structures important for its coordination and regulation.
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spelling pubmed-57724362018-01-26 Altered power spectral density in the resting-state sensorimotor network in patients with myotonic dystrophy type 1 Park, Jin-Sung Seo, Jeehye Cha, Hyunsil Song, Hui-Jin Lee, Sang-Hoon Jang, Kyung Eun Lee, Hui Joong Park, Juyoung Lee, Ho-Won Chang, Yongmin Sci Rep Article Myotonic dystrophy type 1 (DM1) is a multisystemic disease that involves the brain with several neurological symptoms. Although there were few imaging studies on DM1, no studies have investigated functional alterations in the sensorimotor network at rest in patients with DM1. In the current study, a power spectral density (PSD) analysis of resting-state fMRI data was performed to assess possible alteration in spontaneous neural activity of the sensorimotor network in patients with DM1. Compared to healthy controls, patients with DM1 showed higher PSD responses in the orbitofrontal cortex, parahippocampus and basal ganglia (corrected P < 0.05). Patients with DM1 showed higher PSD responses in white matter structures associated with motor function (corrected P < 0.05). Furthermore, correlation analysis indicated that the brain regions showing PSD differences were correlated with measures of motor performance (P < 0.05). In gray matter, our findings suggest that motor disability in DM1 is not an isolated deterioration of the motor power but a multimodal dysfunction that also involves the visual system. In addition, the widespread PSD alteration in white matter structures suggest that motor deficits in DM1 involve motor movement structures as well as structures important for its coordination and regulation. Nature Publishing Group UK 2018-01-17 /pmc/articles/PMC5772436/ /pubmed/29343751 http://dx.doi.org/10.1038/s41598-018-19217-0 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Park, Jin-Sung
Seo, Jeehye
Cha, Hyunsil
Song, Hui-Jin
Lee, Sang-Hoon
Jang, Kyung Eun
Lee, Hui Joong
Park, Juyoung
Lee, Ho-Won
Chang, Yongmin
Altered power spectral density in the resting-state sensorimotor network in patients with myotonic dystrophy type 1
title Altered power spectral density in the resting-state sensorimotor network in patients with myotonic dystrophy type 1
title_full Altered power spectral density in the resting-state sensorimotor network in patients with myotonic dystrophy type 1
title_fullStr Altered power spectral density in the resting-state sensorimotor network in patients with myotonic dystrophy type 1
title_full_unstemmed Altered power spectral density in the resting-state sensorimotor network in patients with myotonic dystrophy type 1
title_short Altered power spectral density in the resting-state sensorimotor network in patients with myotonic dystrophy type 1
title_sort altered power spectral density in the resting-state sensorimotor network in patients with myotonic dystrophy type 1
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772436/
https://www.ncbi.nlm.nih.gov/pubmed/29343751
http://dx.doi.org/10.1038/s41598-018-19217-0
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