The protective role of DOT1L in UV-induced melanomagenesis

The DOT1L histone H3 lysine 79 (H3K79) methyltransferase plays an oncogenic role in MLL-rearranged leukemogenesis. Here, we demonstrate that, in contrast to MLL-rearranged leukemia, DOT1L plays a protective role in ultraviolet radiation (UVR)-induced melanoma development. Specifically, the DOT1L gen...

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Detalles Bibliográficos
Autores principales: Zhu, Bo, Chen, Shuyang, Wang, Hongshen, Yin, Chengqian, Han, Changpeng, Peng, Cong, Liu, Zhaoqian, Wan, Lixin, Zhang, Xiaoyang, Zhang, Jie, Lian, Christine G., Ma, Peilin, Xu, Zhi-xiang, Prince, Sharon, Wang, Tao, Gao, Xiumei, Shi, Yujiang, Liu, Dali, Liu, Min, Wei, Wenyi, Wei, Zhi, Pan, Jingxuan, Wang, Yongjun, Xuan, Zhenyu, Hess, Jay, Hayward, Nicholas K., Goding, Colin R., Chen, Xiang, Zhou, Jun, Cui, Rutao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772495/
https://www.ncbi.nlm.nih.gov/pubmed/29343685
http://dx.doi.org/10.1038/s41467-017-02687-7

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