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Alanine mutation of the catalytic sites of Pantothenate Synthetase causes distinct conformational changes in the ATP binding region

The enzyme Pantothenate synthetase (PS) represents a potential drug target in Mycobacterium tuberculosis. Its X-ray crystallographic structure has demonstrated the significance and importance of conserved active site residues including His44, His47, Asn69, Gln72, Lys160 and Gln164 in substrate bindi...

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Detalles Bibliográficos
Autores principales:	Pandey, Bharati, Grover, Sonam, Goyal, Sukriti, Kumari, Anchala, Singh, Aditi, Jamal, Salma, Kaur, Jagdeep, Grover, Abhinav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772511/ https://www.ncbi.nlm.nih.gov/pubmed/29343701 http://dx.doi.org/10.1038/s41598-017-19075-2

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