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The neural correlates of the unified percept of alcohol-related craving: a fMRI and EEG study

Alcohol addiction is accompanied by aberrant neural activity. Previously, task-based fMRI and resting-state EEG studies have revealed that craving, a critical component of addiction, is linked to abnormal activity in cortical regions including the dorsal anterior cingulate cortex (dACC), nucleus acc...

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Autores principales: Huang, Yuefeng, Mohan, Anusha, De Ridder, Dirk, Sunaert, Stefan, Vanneste, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772563/
https://www.ncbi.nlm.nih.gov/pubmed/29343732
http://dx.doi.org/10.1038/s41598-017-18471-y
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author Huang, Yuefeng
Mohan, Anusha
De Ridder, Dirk
Sunaert, Stefan
Vanneste, Sven
author_facet Huang, Yuefeng
Mohan, Anusha
De Ridder, Dirk
Sunaert, Stefan
Vanneste, Sven
author_sort Huang, Yuefeng
collection PubMed
description Alcohol addiction is accompanied by aberrant neural activity. Previously, task-based fMRI and resting-state EEG studies have revealed that craving, a critical component of addiction, is linked to abnormal activity in cortical regions including the dorsal anterior cingulate cortex (dACC), nucleus accumbens (NAcc), posterior cingulate cortex (PCC) and pregenual anterior cingulate cortex (pgACC), etc. In this study, we combine these two imaging techniques to investigate a group of alcohol-addicted patients and provide convergent evidence for the neural correlates of craving not only in alcohol but substance abuse in general. We observe abnormal BOLD signal levels in the dACC, NAcc, pgACC, PCC, amygdala, and parahippocampus (PHC) in a cue-reactivity fMRI experiment. These findings are consistent with increased beta-band activity in the dACC and pgACC in resting-state EEG. We further observe desynchronization characterized by decreased functional connectivity in cue-based fMRI and hypersynchronization characterized by increased functional connectivity between these regions in the theta frequency band. The results of our study show a consistent pattern of alcohol craving elicited by external cues and internal desires. Given the advantage of superior spatial and temporal resolution, we hypothesize a “central craving network” that integrates the different aspects of alcohol addiction into a unified percept.
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spelling pubmed-57725632018-01-26 The neural correlates of the unified percept of alcohol-related craving: a fMRI and EEG study Huang, Yuefeng Mohan, Anusha De Ridder, Dirk Sunaert, Stefan Vanneste, Sven Sci Rep Article Alcohol addiction is accompanied by aberrant neural activity. Previously, task-based fMRI and resting-state EEG studies have revealed that craving, a critical component of addiction, is linked to abnormal activity in cortical regions including the dorsal anterior cingulate cortex (dACC), nucleus accumbens (NAcc), posterior cingulate cortex (PCC) and pregenual anterior cingulate cortex (pgACC), etc. In this study, we combine these two imaging techniques to investigate a group of alcohol-addicted patients and provide convergent evidence for the neural correlates of craving not only in alcohol but substance abuse in general. We observe abnormal BOLD signal levels in the dACC, NAcc, pgACC, PCC, amygdala, and parahippocampus (PHC) in a cue-reactivity fMRI experiment. These findings are consistent with increased beta-band activity in the dACC and pgACC in resting-state EEG. We further observe desynchronization characterized by decreased functional connectivity in cue-based fMRI and hypersynchronization characterized by increased functional connectivity between these regions in the theta frequency band. The results of our study show a consistent pattern of alcohol craving elicited by external cues and internal desires. Given the advantage of superior spatial and temporal resolution, we hypothesize a “central craving network” that integrates the different aspects of alcohol addiction into a unified percept. Nature Publishing Group UK 2018-01-17 /pmc/articles/PMC5772563/ /pubmed/29343732 http://dx.doi.org/10.1038/s41598-017-18471-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Huang, Yuefeng
Mohan, Anusha
De Ridder, Dirk
Sunaert, Stefan
Vanneste, Sven
The neural correlates of the unified percept of alcohol-related craving: a fMRI and EEG study
title The neural correlates of the unified percept of alcohol-related craving: a fMRI and EEG study
title_full The neural correlates of the unified percept of alcohol-related craving: a fMRI and EEG study
title_fullStr The neural correlates of the unified percept of alcohol-related craving: a fMRI and EEG study
title_full_unstemmed The neural correlates of the unified percept of alcohol-related craving: a fMRI and EEG study
title_short The neural correlates of the unified percept of alcohol-related craving: a fMRI and EEG study
title_sort neural correlates of the unified percept of alcohol-related craving: a fmri and eeg study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772563/
https://www.ncbi.nlm.nih.gov/pubmed/29343732
http://dx.doi.org/10.1038/s41598-017-18471-y
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