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Differential tissue specific, temporal and spatial expression patterns of the Aggrecan gene is modulated by independent enhancer elements
The transcriptional mechanism through which chondrocytes control the spatial and temporal composition of the cartilage tissue has remained largely elusive. The central aim of this study was to identify whether transcriptional enhancers played a role in the organisation of the chondrocytes in cartila...
Autores principales: | Li, Ian M. H., Liu, Ke, Neal, Alice, Clegg, Peter D., De Val, Sarah, Bou-Gharios, George |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772622/ https://www.ncbi.nlm.nih.gov/pubmed/29343853 http://dx.doi.org/10.1038/s41598-018-19186-4 |
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