A case of molecularly profiled extraneural medulloblastoma metastases in a child

BACKGROUND: Extraneural metastases are relatively rare manifestations of medulloblastoma. CASE PRESENTATION: We present the case of a young boy with group three MYCN-amplified medulloblastoma. He received multimodal chemotherapy consisting of gross total resection followed by postoperative craniospi...

Descripción completa

Detalles Bibliográficos
Autores principales: Mobark, Nahla Ali, Al-Harbi, Musa, Mosleh, Othman, Santagata, Sandro, Snuderl, Matija, Abedalthagafi, Malak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772742/
https://www.ncbi.nlm.nih.gov/pubmed/29343221
http://dx.doi.org/10.1186/s12881-018-0526-8
_version_ 1783293459084345344
author Mobark, Nahla Ali
Al-Harbi, Musa
Mosleh, Othman
Santagata, Sandro
Snuderl, Matija
Abedalthagafi, Malak
author_facet Mobark, Nahla Ali
Al-Harbi, Musa
Mosleh, Othman
Santagata, Sandro
Snuderl, Matija
Abedalthagafi, Malak
author_sort Mobark, Nahla Ali
collection PubMed
description BACKGROUND: Extraneural metastases are relatively rare manifestations of medulloblastoma. CASE PRESENTATION: We present the case of a young boy with group three MYCN-amplified medulloblastoma. He received multimodal chemotherapy consisting of gross total resection followed by postoperative craniospinal radiation and adjuvant chemotherapy. The patient developed extraneural metastases 4 months after the end of therapy. Literature review identifies the poor prognosis of MYCN-amplified medulloblastomas as well as extraneural metastases; we review the current limitations and future directions of medulloblastoma treatment options. CONCLUSION: To the best of our knowledge, this is the first molecularly characterized report of extraneural metastases of medulloblastoma in a child.
format Online
Article
Text
id pubmed-5772742
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-57727422018-01-26 A case of molecularly profiled extraneural medulloblastoma metastases in a child Mobark, Nahla Ali Al-Harbi, Musa Mosleh, Othman Santagata, Sandro Snuderl, Matija Abedalthagafi, Malak BMC Med Genet Case Report BACKGROUND: Extraneural metastases are relatively rare manifestations of medulloblastoma. CASE PRESENTATION: We present the case of a young boy with group three MYCN-amplified medulloblastoma. He received multimodal chemotherapy consisting of gross total resection followed by postoperative craniospinal radiation and adjuvant chemotherapy. The patient developed extraneural metastases 4 months after the end of therapy. Literature review identifies the poor prognosis of MYCN-amplified medulloblastomas as well as extraneural metastases; we review the current limitations and future directions of medulloblastoma treatment options. CONCLUSION: To the best of our knowledge, this is the first molecularly characterized report of extraneural metastases of medulloblastoma in a child. BioMed Central 2018-01-17 /pmc/articles/PMC5772742/ /pubmed/29343221 http://dx.doi.org/10.1186/s12881-018-0526-8 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Mobark, Nahla Ali
Al-Harbi, Musa
Mosleh, Othman
Santagata, Sandro
Snuderl, Matija
Abedalthagafi, Malak
A case of molecularly profiled extraneural medulloblastoma metastases in a child
title A case of molecularly profiled extraneural medulloblastoma metastases in a child
title_full A case of molecularly profiled extraneural medulloblastoma metastases in a child
title_fullStr A case of molecularly profiled extraneural medulloblastoma metastases in a child
title_full_unstemmed A case of molecularly profiled extraneural medulloblastoma metastases in a child
title_short A case of molecularly profiled extraneural medulloblastoma metastases in a child
title_sort case of molecularly profiled extraneural medulloblastoma metastases in a child
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772742/
https://www.ncbi.nlm.nih.gov/pubmed/29343221
http://dx.doi.org/10.1186/s12881-018-0526-8
work_keys_str_mv AT mobarknahlaali acaseofmolecularlyprofiledextraneuralmedulloblastomametastasesinachild
AT alharbimusa acaseofmolecularlyprofiledextraneuralmedulloblastomametastasesinachild
AT moslehothman acaseofmolecularlyprofiledextraneuralmedulloblastomametastasesinachild
AT santagatasandro acaseofmolecularlyprofiledextraneuralmedulloblastomametastasesinachild
AT snuderlmatija acaseofmolecularlyprofiledextraneuralmedulloblastomametastasesinachild
AT abedalthagafimalak acaseofmolecularlyprofiledextraneuralmedulloblastomametastasesinachild
AT mobarknahlaali caseofmolecularlyprofiledextraneuralmedulloblastomametastasesinachild
AT alharbimusa caseofmolecularlyprofiledextraneuralmedulloblastomametastasesinachild
AT moslehothman caseofmolecularlyprofiledextraneuralmedulloblastomametastasesinachild
AT santagatasandro caseofmolecularlyprofiledextraneuralmedulloblastomametastasesinachild
AT snuderlmatija caseofmolecularlyprofiledextraneuralmedulloblastomametastasesinachild
AT abedalthagafimalak caseofmolecularlyprofiledextraneuralmedulloblastomametastasesinachild

Ejemplares similares