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The Study of Rhabdomyolysis in the Elderly: An Epidemiological Study and Single Center Experience

Rhabdomyolysis is a syndrome caused by injury to skeletal muscle. There is limited data of rhabdomyolysis in the elderly. The objective of this study is to investigate demographic data, etiologies, laboratory values, prognostic factors, and mortality of rhabdomyolysis in the geriatric population. A...

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Autores principales: Wongrakpanich, Supakanya, Kallis, Christos, Prasad, Prithiv, Rangaswami, Janani, Rosenzweig, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772847/
https://www.ncbi.nlm.nih.gov/pubmed/29392076
http://dx.doi.org/10.14336/AD.2017.0304
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author Wongrakpanich, Supakanya
Kallis, Christos
Prasad, Prithiv
Rangaswami, Janani
Rosenzweig, Andrew
author_facet Wongrakpanich, Supakanya
Kallis, Christos
Prasad, Prithiv
Rangaswami, Janani
Rosenzweig, Andrew
author_sort Wongrakpanich, Supakanya
collection PubMed
description Rhabdomyolysis is a syndrome caused by injury to skeletal muscle. There is limited data of rhabdomyolysis in the elderly. The objective of this study is to investigate demographic data, etiologies, laboratory values, prognostic factors, and mortality of rhabdomyolysis in the geriatric population. A 4-years retrospective chart review study was conducted. Our inclusion criteria were age above 65 years and creatinine kinase level excess five times of normal upper limit. Among 167 patients, 47.3% were male. The median age at diagnosis was 80.11 (66-101) years. The duration of follow up in the study ranged from 0 to 48 months. Fall (with or without immobilization) was the most frequent cause of rhabdomyolysis in 56.9%. The mean baseline glomerular filtration rate (GFR), GFR at diagnosis, and peak decline in GFR was 76.94, 48.96, and 54.41 cc/min respectively. The mean CK at diagnosis and peak CK was 5097.22 and 6320.07. There were 45 deaths (21%) over the span of 4 years. Multivariate analysis demonstrated that number of medications pre-admission (Meds No.), peak decline in GFR, and acute kidney injury (AKI) are independent predictors for overall survival for rhabdomyolysis in the elderly. To our knowledge, this is the first epidemiological study of rhabdomyolysis in the elderly. Falls (with and without immobilization) were the most common etiology. Meds No. (>8), peak decline in GFR (<30 cc/min), and evidence of AKI are associated with shorter overall survival and can serve as potential independent prognostic markers for rhabdomyolysis in elderly patients.
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spelling pubmed-57728472018-02-02 The Study of Rhabdomyolysis in the Elderly: An Epidemiological Study and Single Center Experience Wongrakpanich, Supakanya Kallis, Christos Prasad, Prithiv Rangaswami, Janani Rosenzweig, Andrew Aging Dis Orginal Article Rhabdomyolysis is a syndrome caused by injury to skeletal muscle. There is limited data of rhabdomyolysis in the elderly. The objective of this study is to investigate demographic data, etiologies, laboratory values, prognostic factors, and mortality of rhabdomyolysis in the geriatric population. A 4-years retrospective chart review study was conducted. Our inclusion criteria were age above 65 years and creatinine kinase level excess five times of normal upper limit. Among 167 patients, 47.3% were male. The median age at diagnosis was 80.11 (66-101) years. The duration of follow up in the study ranged from 0 to 48 months. Fall (with or without immobilization) was the most frequent cause of rhabdomyolysis in 56.9%. The mean baseline glomerular filtration rate (GFR), GFR at diagnosis, and peak decline in GFR was 76.94, 48.96, and 54.41 cc/min respectively. The mean CK at diagnosis and peak CK was 5097.22 and 6320.07. There were 45 deaths (21%) over the span of 4 years. Multivariate analysis demonstrated that number of medications pre-admission (Meds No.), peak decline in GFR, and acute kidney injury (AKI) are independent predictors for overall survival for rhabdomyolysis in the elderly. To our knowledge, this is the first epidemiological study of rhabdomyolysis in the elderly. Falls (with and without immobilization) were the most common etiology. Meds No. (>8), peak decline in GFR (<30 cc/min), and evidence of AKI are associated with shorter overall survival and can serve as potential independent prognostic markers for rhabdomyolysis in elderly patients. JKL International LLC 2018-02-01 /pmc/articles/PMC5772847/ /pubmed/29392076 http://dx.doi.org/10.14336/AD.2017.0304 Text en Copyright: © 2017 Wongrakpanich et al. http://creativecommons.org/licenses/by/2.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Orginal Article
Wongrakpanich, Supakanya
Kallis, Christos
Prasad, Prithiv
Rangaswami, Janani
Rosenzweig, Andrew
The Study of Rhabdomyolysis in the Elderly: An Epidemiological Study and Single Center Experience
title The Study of Rhabdomyolysis in the Elderly: An Epidemiological Study and Single Center Experience
title_full The Study of Rhabdomyolysis in the Elderly: An Epidemiological Study and Single Center Experience
title_fullStr The Study of Rhabdomyolysis in the Elderly: An Epidemiological Study and Single Center Experience
title_full_unstemmed The Study of Rhabdomyolysis in the Elderly: An Epidemiological Study and Single Center Experience
title_short The Study of Rhabdomyolysis in the Elderly: An Epidemiological Study and Single Center Experience
title_sort study of rhabdomyolysis in the elderly: an epidemiological study and single center experience
topic Orginal Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772847/
https://www.ncbi.nlm.nih.gov/pubmed/29392076
http://dx.doi.org/10.14336/AD.2017.0304
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