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A Fully Functional Drug-Eluting Joint Implant

Despite advances in orthopedic materials, the development of drug-eluting bone and joint implants that can sustain the delivery of the drug and maintain the necessary mechanical strength in order to withstand loading has remained elusive. Here, we demonstrate that modifying the eccentricity of drug...

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Autores principales: Suhardi, VJ, Bichara, DA, Kwok, SJJ, Freiberg, AA, Rubash, H, Malchau, H, Yun, SH, Muratoglu, OK, Oral, E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773111/
https://www.ncbi.nlm.nih.gov/pubmed/29354321
http://dx.doi.org/10.1038/s41551-017-0080
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author Suhardi, VJ
Bichara, DA
Kwok, SJJ
Freiberg, AA
Rubash, H
Malchau, H
Yun, SH
Muratoglu, OK
Oral, E
author_facet Suhardi, VJ
Bichara, DA
Kwok, SJJ
Freiberg, AA
Rubash, H
Malchau, H
Yun, SH
Muratoglu, OK
Oral, E
author_sort Suhardi, VJ
collection PubMed
description Despite advances in orthopedic materials, the development of drug-eluting bone and joint implants that can sustain the delivery of the drug and maintain the necessary mechanical strength in order to withstand loading has remained elusive. Here, we demonstrate that modifying the eccentricity of drug clusters and the percolation threshold in ultrahigh molecular weight polyethylene (UHMWPE) results in maximized drug elution and in the retention of mechanical strength. The optimized UHMWPE eluted antibiotic at a higher concentration for longer than the clinical gold standard antibiotic-eluting bone cement while retaining the mechanical and wear properties of clinically used UHMWPE joint prostheses. Treatment of lapine knees infected with Staphylococcus aureus with the antibiotic-eluting UHMWPE led to complete bacterial eradication and to the absence of detectable systemic effects. We argue that the antibiotic-eluting UHMWPE joint implant is a promising candidate for clinical trials.
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spelling pubmed-57731112018-01-18 A Fully Functional Drug-Eluting Joint Implant Suhardi, VJ Bichara, DA Kwok, SJJ Freiberg, AA Rubash, H Malchau, H Yun, SH Muratoglu, OK Oral, E Nat Biomed Eng Article Despite advances in orthopedic materials, the development of drug-eluting bone and joint implants that can sustain the delivery of the drug and maintain the necessary mechanical strength in order to withstand loading has remained elusive. Here, we demonstrate that modifying the eccentricity of drug clusters and the percolation threshold in ultrahigh molecular weight polyethylene (UHMWPE) results in maximized drug elution and in the retention of mechanical strength. The optimized UHMWPE eluted antibiotic at a higher concentration for longer than the clinical gold standard antibiotic-eluting bone cement while retaining the mechanical and wear properties of clinically used UHMWPE joint prostheses. Treatment of lapine knees infected with Staphylococcus aureus with the antibiotic-eluting UHMWPE led to complete bacterial eradication and to the absence of detectable systemic effects. We argue that the antibiotic-eluting UHMWPE joint implant is a promising candidate for clinical trials. 2017-06-13 2017 /pmc/articles/PMC5773111/ /pubmed/29354321 http://dx.doi.org/10.1038/s41551-017-0080 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms Reprints and permission information is available at www.nature.com/reprints
spellingShingle Article
Suhardi, VJ
Bichara, DA
Kwok, SJJ
Freiberg, AA
Rubash, H
Malchau, H
Yun, SH
Muratoglu, OK
Oral, E
A Fully Functional Drug-Eluting Joint Implant
title A Fully Functional Drug-Eluting Joint Implant
title_full A Fully Functional Drug-Eluting Joint Implant
title_fullStr A Fully Functional Drug-Eluting Joint Implant
title_full_unstemmed A Fully Functional Drug-Eluting Joint Implant
title_short A Fully Functional Drug-Eluting Joint Implant
title_sort fully functional drug-eluting joint implant
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773111/
https://www.ncbi.nlm.nih.gov/pubmed/29354321
http://dx.doi.org/10.1038/s41551-017-0080
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