Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

Malignant mesothelioma (MM) is poorly responsive to systemic cytotoxic chemotherapy and invariably fatal. Here we describe a screen of 94 drugs in 15 exome-sequenced MM lines and the discovery of a subset defined by loss of function of the nuclear deubiquitinase BRCA associated protein-1 (BAP1) that...

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Detalles Bibliográficos
Autores principales: Kolluri, Krishna Kalyan, Alifrangis, Constantine, Kumar, Neelam, Ishii, Yuki, Price, Stacey, Michaut, Magali, Williams, Steven, Barthorpe, Syd, Lightfoot, Howard, Busacca, Sara, Sharkey, Annabel, Yuan, Zhenqiang, Sage, Elizabeth K, Vallath, Sabarinath, Le Quesne, John, Tice, David A, Alrifai, Doraid, von Karstedt, Sylvia, Montinaro, Antonella, Guppy, Naomi, Waller, David A, Nakas, Apostolos, Good, Robert, Holmes, Alan, Walczak, Henning, Fennell, Dean A, Garnett, Mathew, Iorio, Francesco, Wessels, Lodewyk, McDermott, Ultan, Janes, Samuel M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773178/
https://www.ncbi.nlm.nih.gov/pubmed/29345617
http://dx.doi.org/10.7554/eLife.30224

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