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Cortical Merging in S1 as a Substrate for Tactile Input Grouping

Perception is a reconstruction process guided by rules based on knowledge about the world. Little is known about the neural implementation of the rules of object formation in the tactile sensory system. When two close tactile stimuli are delivered simultaneously on the skin, subjects feel a unique s...

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Autores principales: Corbo, Julien, Zennou-Azogui, Yoh’I, Xerri, Christian, Catz, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773279/
https://www.ncbi.nlm.nih.gov/pubmed/29354679
http://dx.doi.org/10.1523/ENEURO.0342-17.2017
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author Corbo, Julien
Zennou-Azogui, Yoh’I
Xerri, Christian
Catz, Nicolas
author_facet Corbo, Julien
Zennou-Azogui, Yoh’I
Xerri, Christian
Catz, Nicolas
author_sort Corbo, Julien
collection PubMed
description Perception is a reconstruction process guided by rules based on knowledge about the world. Little is known about the neural implementation of the rules of object formation in the tactile sensory system. When two close tactile stimuli are delivered simultaneously on the skin, subjects feel a unique sensation, spatially centered between the two stimuli. Voltage-sensitive dye imaging (VSDi) and electrophysiological recordings [local field potentials (LFPs) and single units] were used to extract the cortical representation of two-point tactile stimuli in the primary somatosensory cortex of anesthetized Long-Evans rats. Although layer 4 LFP responses to brief costimulation of the distal region of two digits resembled the sum of individual responses, approximately one-third of single units demonstrated merging-compatible changes. In contrast to previous intrinsic optical imaging studies, VSD activations reflecting layer 2/3 activity were centered between the representations of the digits stimulated alone. This merging was found for every tested distance between the stimulated digits. We discuss this laminar difference as evidence that merging occurs through a buildup stream and depends on the superposition of inputs, which increases with successive stages of sensory processing. These findings show that layers 2/3 are involved in the grouping of sensory inputs. This process that could be inscribed in the cortical computing routine and network organization is likely to promote object formation and implement perception rules.
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spelling pubmed-57732792018-01-19 Cortical Merging in S1 as a Substrate for Tactile Input Grouping Corbo, Julien Zennou-Azogui, Yoh’I Xerri, Christian Catz, Nicolas eNeuro New Research Perception is a reconstruction process guided by rules based on knowledge about the world. Little is known about the neural implementation of the rules of object formation in the tactile sensory system. When two close tactile stimuli are delivered simultaneously on the skin, subjects feel a unique sensation, spatially centered between the two stimuli. Voltage-sensitive dye imaging (VSDi) and electrophysiological recordings [local field potentials (LFPs) and single units] were used to extract the cortical representation of two-point tactile stimuli in the primary somatosensory cortex of anesthetized Long-Evans rats. Although layer 4 LFP responses to brief costimulation of the distal region of two digits resembled the sum of individual responses, approximately one-third of single units demonstrated merging-compatible changes. In contrast to previous intrinsic optical imaging studies, VSD activations reflecting layer 2/3 activity were centered between the representations of the digits stimulated alone. This merging was found for every tested distance between the stimulated digits. We discuss this laminar difference as evidence that merging occurs through a buildup stream and depends on the superposition of inputs, which increases with successive stages of sensory processing. These findings show that layers 2/3 are involved in the grouping of sensory inputs. This process that could be inscribed in the cortical computing routine and network organization is likely to promote object formation and implement perception rules. Society for Neuroscience 2018-01-16 /pmc/articles/PMC5773279/ /pubmed/29354679 http://dx.doi.org/10.1523/ENEURO.0342-17.2017 Text en Copyright © 2018 Corbo et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle New Research
Corbo, Julien
Zennou-Azogui, Yoh’I
Xerri, Christian
Catz, Nicolas
Cortical Merging in S1 as a Substrate for Tactile Input Grouping
title Cortical Merging in S1 as a Substrate for Tactile Input Grouping
title_full Cortical Merging in S1 as a Substrate for Tactile Input Grouping
title_fullStr Cortical Merging in S1 as a Substrate for Tactile Input Grouping
title_full_unstemmed Cortical Merging in S1 as a Substrate for Tactile Input Grouping
title_short Cortical Merging in S1 as a Substrate for Tactile Input Grouping
title_sort cortical merging in s1 as a substrate for tactile input grouping
topic New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773279/
https://www.ncbi.nlm.nih.gov/pubmed/29354679
http://dx.doi.org/10.1523/ENEURO.0342-17.2017
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