Cargando…

Decrement of Serum Vitamin D Level After Stroke

OBJECTIVE: To investigate the serum vitamin D level and its determinant factors in stroke patients. METHODS: Fifty-one stroke patients who had documented serum level of 25-hydroxyvitamin D(25(OH)D) were included. Patients were divided into subacute (n=23) and chronic groups (n=28). The mean levels o...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Kiyoung, Cho, Kye Hee, Im, Sang Hee, Choi, Jaewoo, Yu, Junghoon, Kim, MinYoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Academy of Rehabilitation Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773437/
https://www.ncbi.nlm.nih.gov/pubmed/29354570
http://dx.doi.org/10.5535/arm.2017.41.6.944
_version_ 1783293556735082496
author Kim, Kiyoung
Cho, Kye Hee
Im, Sang Hee
Choi, Jaewoo
Yu, Junghoon
Kim, MinYoung
author_facet Kim, Kiyoung
Cho, Kye Hee
Im, Sang Hee
Choi, Jaewoo
Yu, Junghoon
Kim, MinYoung
author_sort Kim, Kiyoung
collection PubMed
description OBJECTIVE: To investigate the serum vitamin D level and its determinant factors in stroke patients. METHODS: Fifty-one stroke patients who had documented serum level of 25-hydroxyvitamin D(25(OH)D) were included. Patients were divided into subacute (n=23) and chronic groups (n=28). The mean levels of 25(OH)D of the two groups were compared. Correlations between each 25(OH)D level and post-stroke duration were also analyzed. To assess other possible influencing factors, patients were subdivided by ambulation ability and feeding methods for comparison of 25(OH)D level. RESULTS: The mean level of 25(OH)D was significantly lower in the chronic group than in the subacute group (12.3 vs. 16.3 ng/mL; p<0.05). The serum 25(OH)D level decreased according to the duration after stroke (r=−0.52, p=0.01). Patients with a history of total parenteral nutrition had lower 25(OH)D levels than subjects who had enteral nutrition in the subacute group (7.3 vs. 18.8 ng/mL; p<0.01). However, the levels of 25(OH)D were not different between the oral feeding and tube feeding groups. Among the chronic group subjects, patients who could walk without assistance had higher 25(OH)D levels than non-ambulatory patients (ambulatory vs. non-ambulatory group; 18.3 vs. 11.3 ng/mL; p<0.05). CONCLUSION: After stroke onset, serum vitamin D level decreases with time regardless of feeding methods, and total parenteral nutrition may aggravate its deficiency. In terms of long-term care, non-ambulatory patients might be at a higher risk of vitamin D deficiency. Supplementation of vitamin D should be considered especially for stroke patients who are non-ambulatory and on total parenteral nutrition.
format Online
Article
Text
id pubmed-5773437
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Korean Academy of Rehabilitation Medicine
record_format MEDLINE/PubMed
spelling pubmed-57734372018-01-21 Decrement of Serum Vitamin D Level After Stroke Kim, Kiyoung Cho, Kye Hee Im, Sang Hee Choi, Jaewoo Yu, Junghoon Kim, MinYoung Ann Rehabil Med Original Article OBJECTIVE: To investigate the serum vitamin D level and its determinant factors in stroke patients. METHODS: Fifty-one stroke patients who had documented serum level of 25-hydroxyvitamin D(25(OH)D) were included. Patients were divided into subacute (n=23) and chronic groups (n=28). The mean levels of 25(OH)D of the two groups were compared. Correlations between each 25(OH)D level and post-stroke duration were also analyzed. To assess other possible influencing factors, patients were subdivided by ambulation ability and feeding methods for comparison of 25(OH)D level. RESULTS: The mean level of 25(OH)D was significantly lower in the chronic group than in the subacute group (12.3 vs. 16.3 ng/mL; p<0.05). The serum 25(OH)D level decreased according to the duration after stroke (r=−0.52, p=0.01). Patients with a history of total parenteral nutrition had lower 25(OH)D levels than subjects who had enteral nutrition in the subacute group (7.3 vs. 18.8 ng/mL; p<0.01). However, the levels of 25(OH)D were not different between the oral feeding and tube feeding groups. Among the chronic group subjects, patients who could walk without assistance had higher 25(OH)D levels than non-ambulatory patients (ambulatory vs. non-ambulatory group; 18.3 vs. 11.3 ng/mL; p<0.05). CONCLUSION: After stroke onset, serum vitamin D level decreases with time regardless of feeding methods, and total parenteral nutrition may aggravate its deficiency. In terms of long-term care, non-ambulatory patients might be at a higher risk of vitamin D deficiency. Supplementation of vitamin D should be considered especially for stroke patients who are non-ambulatory and on total parenteral nutrition. Korean Academy of Rehabilitation Medicine 2017-12 2017-12-28 /pmc/articles/PMC5773437/ /pubmed/29354570 http://dx.doi.org/10.5535/arm.2017.41.6.944 Text en Copyright © 2017 by Korean Academy of Rehabilitation Medicine http://creativecommons.org/licenses/by-nc/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Kiyoung
Cho, Kye Hee
Im, Sang Hee
Choi, Jaewoo
Yu, Junghoon
Kim, MinYoung
Decrement of Serum Vitamin D Level After Stroke
title Decrement of Serum Vitamin D Level After Stroke
title_full Decrement of Serum Vitamin D Level After Stroke
title_fullStr Decrement of Serum Vitamin D Level After Stroke
title_full_unstemmed Decrement of Serum Vitamin D Level After Stroke
title_short Decrement of Serum Vitamin D Level After Stroke
title_sort decrement of serum vitamin d level after stroke
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773437/
https://www.ncbi.nlm.nih.gov/pubmed/29354570
http://dx.doi.org/10.5535/arm.2017.41.6.944
work_keys_str_mv AT kimkiyoung decrementofserumvitamindlevelafterstroke
AT chokyehee decrementofserumvitamindlevelafterstroke
AT imsanghee decrementofserumvitamindlevelafterstroke
AT choijaewoo decrementofserumvitamindlevelafterstroke
AT yujunghoon decrementofserumvitamindlevelafterstroke
AT kimminyoung decrementofserumvitamindlevelafterstroke