Cargando…

3D-QSAR study of steroidal and azaheterocyclic human aromatase inhibitors using quantitative profile of protein–ligand interactions

Aromatase is a member of the cytochrome P450 superfamily responsible for a key step in the biosynthesis of estrogens. As estrogens are involved in the control of important reproduction-related processes, including sexual differentiation and maturation, aromatase is a potential target for endocrine d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Sehan, Barron, Mace G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773458/ https://www.ncbi.nlm.nih.gov/pubmed/29349513 http://dx.doi.org/10.1186/s13321-017-0253-8

Ejemplares similares

3D QSAR Studies, Pharmacophore Modeling and Virtual Screening on a Series of Steroidal Aromatase Inhibitors
por: Xie, Huiding, et al.
Publicado: (2014)

Regioselective ring opening of aziridine for synthesizing azaheterocycle
por: Srivastava, Nikhil, et al.
Publicado: (2023)

Impact of nonsteroidal aromatase inhibitors on steroid profile in a Chinese population
por: Xing, Yanyi, et al.
Publicado: (2017)

Aromatase and Dual Aromatase-Steroid Sulfatase Inhibitors from the Letrozole and Vorozole Templates
por: Wood, Paul M, et al.
Publicado: (2011)

Microwave Assisted Reactions of Azaheterocycles Formedicinal Chemistry Applications
por: Amariucai-Mantu, Dorina, et al.
Publicado: (2020)

Bone Safety Profile of Steroidal Aromatase Inhibitor in Comparison to Nonsteroidal Aromatase Inhibitors in Postmenopausal Women with Breast Cancer: A Network Meta-Analysis
por: Chen, Shanshan, et al.
Publicado: (2022)

Towards understanding aromatase inhibitory activity via QSAR modeling
por: Shoombuatong, Watshara, et al.
Publicado: (2018)

Development of Drugs with Direct Antiviral Action Based on Azaheterocyclic Systems
por: Charushin, V. N., et al.
Publicado: (2022)

Long-term complete remission of metastatic breast cancer, induced by a steroidal aromatase inhibitor after failure of a non-steroidal aromatase inhibitor
por: Shioi, Yoshihiro, et al.
Publicado: (2014)

Structure-Based Understanding of Binding Affinity and Mode of Estrogen Receptor α Agonists and Antagonists
por: Lee, Sehan, et al.
Publicado: (2017)

Aromatase inhibitory activity of 1,4-naphthoquinone derivatives and QSAR study
por: Prachayasittikul, Veda, et al.
Publicado: (2017)

2D-QSAR and 3D-QSAR Analyses for EGFR Inhibitors
por: Zhao, Manman, et al.
Publicado: (2017)

A Review on the Synthesis of Fluorescent Five- and Six-Membered Ring Azaheterocycles
por: Zbancioc, Gheorghita, et al.
Publicado: (2022)

Endocrinological and clinical evaluation of exemestane, a new steroidal aromatase inhibitor.
por: Zilembo, N., et al.
Publicado: (1995)

Identification and Quantification of Novel Major Metabolites of the Steroidal Aromatase Inhibitor, Exemestane
por: Luo, Shaman, et al.
Publicado: (2018)

Correction: Xie, H.; et al. 3D QSAR Studies, Pharmacophore Modeling and Virtual Screening on a Series of Steroidal Aromatase Inhibitors. Int. J. Mol. Sci. 2014, 15, 20927–20947
por: Xie, Huiding, et al.
Publicado: (2015)

Synthetic Strategies for 5- and 6-Membered Ring Azaheterocycles Facilitated by Iminyl Radicals
por: Walton, John C.
Publicado: (2016)

Construction of azaheterocycles via Pd-catalyzed migratory cycloannulation reaction of unactivated alkenes
por: Wang, Jin-Ping, et al.
Publicado: (2022)

Steroidal aromatase inhibitors have a more favorable effect on lipid profiles than nonsteroidal aromatase inhibitors in postmenopausal women with early breast cancer: a prospective cohort study
por: Wang, Xue, et al.
Publicado: (2020)

Differences between the non-steroidal aromatase inhibitors anastrozole and letrozole – of clinical importance?
por: Geisler, J
Publicado: (2011)

Sulfonamide-Based Azaheterocyclic Schiff Base Derivatives as Potential Carbonic Anhydrase Inhibitors: Synthesis, Cytotoxicity, and Enzyme Inhibitory Kinetics
por: Abas, Mujahid, et al.
Publicado: (2020)

Probing the origins of aromatase inhibitory activity of disubstituted coumarins via QSAR and molecular docking
por: Worachartcheewan, Apilak, et al.
Publicado: (2014)

CORRIGENDUM to “Steroidal aromatase inhibitors have a more favorable effect on lipid profiles than nonsteroidal aromatase inhibitors in postmenopausal women with early breast cancer: a prospective cohort study”
Publicado: (2020)

A highly site-selective radical sp(3) C–H amination of azaheterocycles
por: Bentley, Keith W., et al.
Publicado: (2018)

Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1
por: Fusi, Camilla, et al.
Publicado: (2014)

A yeast screen system for aromatase inhibitors and ligands for androgen receptor: yeast cells transformed with aromatase and androgen receptor.
por: Mak, P, et al.
Publicado: (1999)

Dexmethylphenidate-Induced Rhabdomyolysis by Interaction With Aromatase Inhibitor
por: Huang, Derrick, et al.
Publicado: (2022)

Binding mode of triazole derivatives as aromatase inhibitors based on docking, protein ligand interaction fingerprinting, and molecular dynamics simulation studies
por: Mojaddami, Ayyub, et al.
Publicado: (2017)

Effects of steroidal and nonsteroidal aromatase inhibitors on markers of bone turnover in healthy postmenopausal women
por: Goss, Paul E, et al.
Publicado: (2007)

Azaheterocyclic diphenylmethanol chiral solvating agents for the NMR chiral discrimination of alpha-substituted carboxylic acids
por: Li, Gao-Wei, et al.
Publicado: (2020)

Unusual light-driven amplification through unexpected regioselective photogeneration of five-membered azaheterocyclic AIEgen
por: Li, Qiyao, et al.
Publicado: (2020)

Sequencing of aromatase inhibitors
por: Bertelli, G
Publicado: (2005)

Investigations of Structural Requirements for BRD4 Inhibitors through Ligand- and Structure-Based 3D QSAR Approaches
por: Tahir, Adeena, et al.
Publicado: (2018)

Lack of cross-resistance between non-steroidal and steroidal aromatase inhibitors in breast cancer patients: the potential role of the adipokine leptin
por: Bahrami, Nazli, et al.
Publicado: (2021)

The reactions of 2-ethoxymethylidene-3-oxo esters and their analogues with 5-aminotetrazole as a way to novel azaheterocycles
por: Goryaeva, Marina V, et al.
Publicado: (2015)

Two Annulated Azaheterocyclic Cores Readily Available from a Single Tetrahydroisoquinolonic Castagnoli–Cushman Precursor
por: Karchuganova, Elizaveta, et al.
Publicado: (2020)

Organizing Effects of Sex Steroids on Brain Aromatase Activity in Quail
por: Cornil, Charlotte A., et al.
Publicado: (2011)

Ligand-based pharmacophore modeling and QSAR approach to identify potential dengue protease inhibitors
por: Poola, Anushka A., et al.
Publicado: (2023)

Docking, Interaction Fingerprint, and Three-Dimensional Quantitative Structure–Activity Relationship (3D-QSAR) of Sigma1 Receptor Ligands, Analogs of the Neuroprotective Agent RC-33
por: Velázquez-Libera, José Luis, et al.
Publicado: (2019)

Bone loss and the aromatase inhibitors
por: Lester, J, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_b8d4eu28gf31iu035l6mps2vja