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Dynamic all-optical drug screening on cardiac voltage-gated ion channels

Voltage-gated ion channels (VGCs) are prime targets for the pharmaceutical industry, but drug profiling on VGCs is challenging, since drug interactions are confined to specific conformational channel states mediated by changes in transmembrane potential. Here we combined various optogenetic tools to...

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Detalles Bibliográficos
Autores principales:	Streit, Jonas, Kleinlogel, Sonja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773578/ https://www.ncbi.nlm.nih.gov/pubmed/29348631 http://dx.doi.org/10.1038/s41598-018-19412-z

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