Cargando…

Amygdala-orbitofrontal structural and functional connectivity in females with anxiety disorders, with and without a history of conduct disorder

Conduct disorder (CD) and anxiety disorders (ADs) are often comorbid and both are characterized by hyper-sensitivity to threat, and reduced structural and functional connectivity between the amygdala and orbitofrontal cortex (OFC). Previous studies of CD have not taken account of ADs nor directly co...

Descripción completa

Detalles Bibliográficos
Autores principales: Lindner, Philip, Flodin, Pär, Larm, Peter, Budhiraja, Meenal, Savic-Berglund, Ivanka, Jokinen, Jussi, Tiihonen, Jari, Hodgins, Sheilagh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773614/
https://www.ncbi.nlm.nih.gov/pubmed/29348532
http://dx.doi.org/10.1038/s41598-018-19569-7
_version_ 1783293598179000320
author Lindner, Philip
Flodin, Pär
Larm, Peter
Budhiraja, Meenal
Savic-Berglund, Ivanka
Jokinen, Jussi
Tiihonen, Jari
Hodgins, Sheilagh
author_facet Lindner, Philip
Flodin, Pär
Larm, Peter
Budhiraja, Meenal
Savic-Berglund, Ivanka
Jokinen, Jussi
Tiihonen, Jari
Hodgins, Sheilagh
author_sort Lindner, Philip
collection PubMed
description Conduct disorder (CD) and anxiety disorders (ADs) are often comorbid and both are characterized by hyper-sensitivity to threat, and reduced structural and functional connectivity between the amygdala and orbitofrontal cortex (OFC). Previous studies of CD have not taken account of ADs nor directly compared connectivity in the two disorders. We examined three groups of young women: 23 presenting CD and lifetime AD; 30 presenting lifetime AD and not CD; and 17 with neither disorder (ND). Participants completed clinical assessments and diffusion-weighted and resting-state functional MRI scans. The uncinate fasciculus was reconstructed using tractography and manual dissection, and structural measures extracted. Correlations of resting-state activity between amygdala and OFC seeds were computed. The CD + AD and AD groups showed similarly reduced structural integrity of the left uncinate compared to ND, even after adjusting for IQ, psychiatric comorbidity, and childhood maltreatment. Uncinate integrity was associated with harm avoidance traits among AD-only women, and with the interaction of poor anger control and anxiety symptoms among CD + AD women. Groups did not differ in functional connectivity. Reduced uncinate integrity observed in CD + AD and AD-only women may reflect deficient emotion regulation in response to threat, common to both disorders, while other neural mechanisms determine the behavioral response.
format Online
Article
Text
id pubmed-5773614
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-57736142018-01-26 Amygdala-orbitofrontal structural and functional connectivity in females with anxiety disorders, with and without a history of conduct disorder Lindner, Philip Flodin, Pär Larm, Peter Budhiraja, Meenal Savic-Berglund, Ivanka Jokinen, Jussi Tiihonen, Jari Hodgins, Sheilagh Sci Rep Article Conduct disorder (CD) and anxiety disorders (ADs) are often comorbid and both are characterized by hyper-sensitivity to threat, and reduced structural and functional connectivity between the amygdala and orbitofrontal cortex (OFC). Previous studies of CD have not taken account of ADs nor directly compared connectivity in the two disorders. We examined three groups of young women: 23 presenting CD and lifetime AD; 30 presenting lifetime AD and not CD; and 17 with neither disorder (ND). Participants completed clinical assessments and diffusion-weighted and resting-state functional MRI scans. The uncinate fasciculus was reconstructed using tractography and manual dissection, and structural measures extracted. Correlations of resting-state activity between amygdala and OFC seeds were computed. The CD + AD and AD groups showed similarly reduced structural integrity of the left uncinate compared to ND, even after adjusting for IQ, psychiatric comorbidity, and childhood maltreatment. Uncinate integrity was associated with harm avoidance traits among AD-only women, and with the interaction of poor anger control and anxiety symptoms among CD + AD women. Groups did not differ in functional connectivity. Reduced uncinate integrity observed in CD + AD and AD-only women may reflect deficient emotion regulation in response to threat, common to both disorders, while other neural mechanisms determine the behavioral response. Nature Publishing Group UK 2018-01-18 /pmc/articles/PMC5773614/ /pubmed/29348532 http://dx.doi.org/10.1038/s41598-018-19569-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lindner, Philip
Flodin, Pär
Larm, Peter
Budhiraja, Meenal
Savic-Berglund, Ivanka
Jokinen, Jussi
Tiihonen, Jari
Hodgins, Sheilagh
Amygdala-orbitofrontal structural and functional connectivity in females with anxiety disorders, with and without a history of conduct disorder
title Amygdala-orbitofrontal structural and functional connectivity in females with anxiety disorders, with and without a history of conduct disorder
title_full Amygdala-orbitofrontal structural and functional connectivity in females with anxiety disorders, with and without a history of conduct disorder
title_fullStr Amygdala-orbitofrontal structural and functional connectivity in females with anxiety disorders, with and without a history of conduct disorder
title_full_unstemmed Amygdala-orbitofrontal structural and functional connectivity in females with anxiety disorders, with and without a history of conduct disorder
title_short Amygdala-orbitofrontal structural and functional connectivity in females with anxiety disorders, with and without a history of conduct disorder
title_sort amygdala-orbitofrontal structural and functional connectivity in females with anxiety disorders, with and without a history of conduct disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773614/
https://www.ncbi.nlm.nih.gov/pubmed/29348532
http://dx.doi.org/10.1038/s41598-018-19569-7
work_keys_str_mv AT lindnerphilip amygdalaorbitofrontalstructuralandfunctionalconnectivityinfemaleswithanxietydisorderswithandwithoutahistoryofconductdisorder
AT flodinpar amygdalaorbitofrontalstructuralandfunctionalconnectivityinfemaleswithanxietydisorderswithandwithoutahistoryofconductdisorder
AT larmpeter amygdalaorbitofrontalstructuralandfunctionalconnectivityinfemaleswithanxietydisorderswithandwithoutahistoryofconductdisorder
AT budhirajameenal amygdalaorbitofrontalstructuralandfunctionalconnectivityinfemaleswithanxietydisorderswithandwithoutahistoryofconductdisorder
AT savicberglundivanka amygdalaorbitofrontalstructuralandfunctionalconnectivityinfemaleswithanxietydisorderswithandwithoutahistoryofconductdisorder
AT jokinenjussi amygdalaorbitofrontalstructuralandfunctionalconnectivityinfemaleswithanxietydisorderswithandwithoutahistoryofconductdisorder
AT tiihonenjari amygdalaorbitofrontalstructuralandfunctionalconnectivityinfemaleswithanxietydisorderswithandwithoutahistoryofconductdisorder
AT hodginssheilagh amygdalaorbitofrontalstructuralandfunctionalconnectivityinfemaleswithanxietydisorderswithandwithoutahistoryofconductdisorder