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Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis
In addition to motor neurone degeneration, up to 50% of amyotrophic lateral sclerosis (ALS) patients present with cognitive decline. Understanding the neurobiological changes underlying these cognitive deficits is critical, as cognitively impaired patients exhibit a shorter survival time from sympto...
Autores principales: | Henstridge, Christopher M., Sideris, Dimitrios I., Carroll, Emily, Rotariu, Sanziana, Salomonsson, Sally, Tzioras, Makis, McKenzie, Chris-Anne, Smith, Colin, von Arnim, Christine A. F., Ludolph, Albert C., Lulé, Dorothée, Leighton, Danielle, Warner, Jon, Cleary, Elaine, Newton, Judith, Swingler, Robert, Chandran, Siddharthan, Gillingwater, Thomas H., Abrahams, Sharon, Spires-Jones, Tara L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773656/ https://www.ncbi.nlm.nih.gov/pubmed/29273900 http://dx.doi.org/10.1007/s00401-017-1797-4 |
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