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Prime-boost vaccination with recombinant protein and adenovirus-vector expressing Plasmodium vivax circumsporozoite protein (CSP) partially protects mice against Pb/Pv sporozoite challenge

Vaccine development against Plasmodium vivax malaria lags behind that for Plasmodium falciparum. To narrow this gap, we administered recombinant antigens based on P. vivax circumsporozoite protein (CSP) to mice. We expressed in Pichia pastoris two chimeric proteins by merging the three central repea...

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Detalles Bibliográficos
Autores principales:	de Camargo, Tarsila Mendes, de Freitas, Elisângela Oliveira, Gimenez, Alba Marina, Lima, Luciana Chagas, de Almeida Caramico, Karina, Françoso, Kátia Sanches, Bruna-Romero, Oscar, Andolina, Chiara, Nosten, François, Rénia, Laurent, Ertl, Hildegund C. J., Nussenzweig, Ruth S., Nussenzweig, Victor, Rodrigues, Mauricio M., Reyes-Sandoval, Arturo, Soares, Irene S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773670/ https://www.ncbi.nlm.nih.gov/pubmed/29348479 http://dx.doi.org/10.1038/s41598-017-19063-6

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