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Treprostinil inhibits proliferation and extracellular matrix deposition by fibroblasts through cAMP activation

Idiopathic pulmonary fibrosis (IPF) is characterized by peripheral lung fibrosis and increased interstitial extracellular matrix (ECM) deposition. In IPF, tumor growth factor (TGF)-β1 which is the major stimulus of ECM deposition, and platelet derived growth factor (PDGF)-BB is a potent stimulus of...

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Detalles Bibliográficos
Autores principales:	Lambers, Christopher, Roth, Michael, Jaksch, Peter, Muraközy, Gabriella, Tamm, Michael, Klepetko, Walter, Ghanim, Bahil, Zhao, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773699/ https://www.ncbi.nlm.nih.gov/pubmed/29348469 http://dx.doi.org/10.1038/s41598-018-19294-1

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