Oxidative stress via inhibition of the mitochondrial electron transport and Nrf-2-mediated anti-oxidative response regulate the cytotoxic activity of plumbagin

Plumbagin, an anti-cancer agent, is toxic to cells of multiple species. We investigated if plumbagin targets conserved biochemical processes. Plumbagin induced DNA damage and apoptosis in cells of diverse mutational background with comparable potency. A 3–5 fold increase in intracellular oxygen radi...

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Detalles Bibliográficos
Autores principales: Kapur, Arvinder, Beres, Thomas, Rathi, Kavya, Nayak, Amruta P., Czarnecki, Austin, Felder, Mildred, Gillette, Amani, Ericksen, Spencer S., Sampene, Emmanuel, Skala, Melissa C., Barroilhet, Lisa, Patankar, Manish S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773707/
https://www.ncbi.nlm.nih.gov/pubmed/29348410
http://dx.doi.org/10.1038/s41598-018-19261-w

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