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Generation and Characterization of Alloantigen-Specific Regulatory T Cells For Clinical Transplant Tolerance

Donor-specific CD4(+)CD127(−)CD25(+)FOXP3(+) regulatory T cells (AgTregs) have the potential to induce clinical transplant tolerance; however, their expansion ex vivo remains challenging. We optimized a novel expansion protocol to stimulate donor-specific Tregs using soluble 4-trimer CD40 ligand (CD...

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Detalles Bibliográficos
Autores principales:	Mathew, James M., Voss, Jessica H., McEwen, Scott T., Konieczna, Iwona, Chakraborty, Arjun, Huang, Xuemei, He, Jie, Gallon, Lorenzo, Kornbluth, Richard S., Leventhal, Joseph R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773708/ https://www.ncbi.nlm.nih.gov/pubmed/29348660 http://dx.doi.org/10.1038/s41598-018-19621-6

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