LRET Determination of Molecular Distances during pH Gating of the Mammalian Inward Rectifier Kir1.1b

Gating of the mammalian inward rectifier Kir1.1 at the helix bundle crossing (HBC) by intracellular pH is believed to be mediated by conformational changes in the C-terminal domain (CTD). However, the exact motion of the CTD during Kir gating remains controversial. Crystal structures and single-mole...

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Detalles Bibliográficos
Autores principales: Nanazashvili, Mikheil, Sánchez-Rodríguez, Jorge E., Fosque, Ben, Bezanilla, Francisco, Sackin, Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2018
Materias:
Channels and Transporters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773755/
https://www.ncbi.nlm.nih.gov/pubmed/29320699
http://dx.doi.org/10.1016/j.bpj.2017.10.044

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