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Interleukin-6 Genetic Variation and Susceptibility to Gastric Cancer in an Iranian Population

BACKGROUND: Despite recent decrease in the incidence of gastric cancer, it is still a common type of cancer in the north of Iran. Many evaluations have shown that polymorphisms of cytokine genes like that for interleukin 6 (IL-6), which play important roles in regulation of the immune response, can...

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Autores principales: Attar, Marzieh, Mansoori, Maryam, Shahbazi, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773787/
https://www.ncbi.nlm.nih.gov/pubmed/29172275
http://dx.doi.org/10.22034/APJCP.2017.18.11.3025
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author Attar, Marzieh
Mansoori, Maryam
Shahbazi, Majid
author_facet Attar, Marzieh
Mansoori, Maryam
Shahbazi, Majid
author_sort Attar, Marzieh
collection PubMed
description BACKGROUND: Despite recent decrease in the incidence of gastric cancer, it is still a common type of cancer in the north of Iran. Many evaluations have shown that polymorphisms of cytokine genes like that for interleukin 6 (IL-6), which play important roles in regulation of the immune response, can increase the risk of gastric cancer. This study examined the role of the IL-6-174 gene polymorphism in susceptibility in an Iranian population. METHOD: Genomic DNA was extracted from peripheral whole blood of 100 patients and 361 healthy controls. Genotyping was accomplished by the sequence-specific primer-polymerase chain reaction (SSP-PCR) method and statistical analyses were carried out using Fisher’s exact test. Frequencies of the IL-6-174 G/C genotypes were determined under co-dominant, dominant, and recessive genetic models. RESULTS: An association between the polymorphism of IL-6 -174 G/C and susceptibility to gastric cancer was observed. The frequency of G allele was higher in patients (78%) than in controls (70.5 %) (OR=1.48, 95% CI=1.01-2.20, P=0.04). CONCLUSIONS: The high G allele and G/G genotype frequency in patients compared to control subjects suggests that the IL-6 -174 G/C polymorphism may influence the susceptibility to gastric cancer. In addition, the demographic information showed that most of the subjects were male (69.0%) that gastric cancer is related to environmental factors.
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spelling pubmed-57737872018-02-01 Interleukin-6 Genetic Variation and Susceptibility to Gastric Cancer in an Iranian Population Attar, Marzieh Mansoori, Maryam Shahbazi, Majid Asian Pac J Cancer Prev Research Article BACKGROUND: Despite recent decrease in the incidence of gastric cancer, it is still a common type of cancer in the north of Iran. Many evaluations have shown that polymorphisms of cytokine genes like that for interleukin 6 (IL-6), which play important roles in regulation of the immune response, can increase the risk of gastric cancer. This study examined the role of the IL-6-174 gene polymorphism in susceptibility in an Iranian population. METHOD: Genomic DNA was extracted from peripheral whole blood of 100 patients and 361 healthy controls. Genotyping was accomplished by the sequence-specific primer-polymerase chain reaction (SSP-PCR) method and statistical analyses were carried out using Fisher’s exact test. Frequencies of the IL-6-174 G/C genotypes were determined under co-dominant, dominant, and recessive genetic models. RESULTS: An association between the polymorphism of IL-6 -174 G/C and susceptibility to gastric cancer was observed. The frequency of G allele was higher in patients (78%) than in controls (70.5 %) (OR=1.48, 95% CI=1.01-2.20, P=0.04). CONCLUSIONS: The high G allele and G/G genotype frequency in patients compared to control subjects suggests that the IL-6 -174 G/C polymorphism may influence the susceptibility to gastric cancer. In addition, the demographic information showed that most of the subjects were male (69.0%) that gastric cancer is related to environmental factors. West Asia Organization for Cancer Prevention 2017 /pmc/articles/PMC5773787/ /pubmed/29172275 http://dx.doi.org/10.22034/APJCP.2017.18.11.3025 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Research Article
Attar, Marzieh
Mansoori, Maryam
Shahbazi, Majid
Interleukin-6 Genetic Variation and Susceptibility to Gastric Cancer in an Iranian Population
title Interleukin-6 Genetic Variation and Susceptibility to Gastric Cancer in an Iranian Population
title_full Interleukin-6 Genetic Variation and Susceptibility to Gastric Cancer in an Iranian Population
title_fullStr Interleukin-6 Genetic Variation and Susceptibility to Gastric Cancer in an Iranian Population
title_full_unstemmed Interleukin-6 Genetic Variation and Susceptibility to Gastric Cancer in an Iranian Population
title_short Interleukin-6 Genetic Variation and Susceptibility to Gastric Cancer in an Iranian Population
title_sort interleukin-6 genetic variation and susceptibility to gastric cancer in an iranian population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773787/
https://www.ncbi.nlm.nih.gov/pubmed/29172275
http://dx.doi.org/10.22034/APJCP.2017.18.11.3025
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