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Interleukin-6 Genetic Variation and Susceptibility to Gastric Cancer in an Iranian Population
BACKGROUND: Despite recent decrease in the incidence of gastric cancer, it is still a common type of cancer in the north of Iran. Many evaluations have shown that polymorphisms of cytokine genes like that for interleukin 6 (IL-6), which play important roles in regulation of the immune response, can...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
West Asia Organization for Cancer Prevention
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773787/ https://www.ncbi.nlm.nih.gov/pubmed/29172275 http://dx.doi.org/10.22034/APJCP.2017.18.11.3025 |
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author | Attar, Marzieh Mansoori, Maryam Shahbazi, Majid |
author_facet | Attar, Marzieh Mansoori, Maryam Shahbazi, Majid |
author_sort | Attar, Marzieh |
collection | PubMed |
description | BACKGROUND: Despite recent decrease in the incidence of gastric cancer, it is still a common type of cancer in the north of Iran. Many evaluations have shown that polymorphisms of cytokine genes like that for interleukin 6 (IL-6), which play important roles in regulation of the immune response, can increase the risk of gastric cancer. This study examined the role of the IL-6-174 gene polymorphism in susceptibility in an Iranian population. METHOD: Genomic DNA was extracted from peripheral whole blood of 100 patients and 361 healthy controls. Genotyping was accomplished by the sequence-specific primer-polymerase chain reaction (SSP-PCR) method and statistical analyses were carried out using Fisher’s exact test. Frequencies of the IL-6-174 G/C genotypes were determined under co-dominant, dominant, and recessive genetic models. RESULTS: An association between the polymorphism of IL-6 -174 G/C and susceptibility to gastric cancer was observed. The frequency of G allele was higher in patients (78%) than in controls (70.5 %) (OR=1.48, 95% CI=1.01-2.20, P=0.04). CONCLUSIONS: The high G allele and G/G genotype frequency in patients compared to control subjects suggests that the IL-6 -174 G/C polymorphism may influence the susceptibility to gastric cancer. In addition, the demographic information showed that most of the subjects were male (69.0%) that gastric cancer is related to environmental factors. |
format | Online Article Text |
id | pubmed-5773787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-57737872018-02-01 Interleukin-6 Genetic Variation and Susceptibility to Gastric Cancer in an Iranian Population Attar, Marzieh Mansoori, Maryam Shahbazi, Majid Asian Pac J Cancer Prev Research Article BACKGROUND: Despite recent decrease in the incidence of gastric cancer, it is still a common type of cancer in the north of Iran. Many evaluations have shown that polymorphisms of cytokine genes like that for interleukin 6 (IL-6), which play important roles in regulation of the immune response, can increase the risk of gastric cancer. This study examined the role of the IL-6-174 gene polymorphism in susceptibility in an Iranian population. METHOD: Genomic DNA was extracted from peripheral whole blood of 100 patients and 361 healthy controls. Genotyping was accomplished by the sequence-specific primer-polymerase chain reaction (SSP-PCR) method and statistical analyses were carried out using Fisher’s exact test. Frequencies of the IL-6-174 G/C genotypes were determined under co-dominant, dominant, and recessive genetic models. RESULTS: An association between the polymorphism of IL-6 -174 G/C and susceptibility to gastric cancer was observed. The frequency of G allele was higher in patients (78%) than in controls (70.5 %) (OR=1.48, 95% CI=1.01-2.20, P=0.04). CONCLUSIONS: The high G allele and G/G genotype frequency in patients compared to control subjects suggests that the IL-6 -174 G/C polymorphism may influence the susceptibility to gastric cancer. In addition, the demographic information showed that most of the subjects were male (69.0%) that gastric cancer is related to environmental factors. West Asia Organization for Cancer Prevention 2017 /pmc/articles/PMC5773787/ /pubmed/29172275 http://dx.doi.org/10.22034/APJCP.2017.18.11.3025 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License |
spellingShingle | Research Article Attar, Marzieh Mansoori, Maryam Shahbazi, Majid Interleukin-6 Genetic Variation and Susceptibility to Gastric Cancer in an Iranian Population |
title | Interleukin-6 Genetic Variation and Susceptibility to Gastric Cancer in an Iranian Population |
title_full | Interleukin-6 Genetic Variation and Susceptibility to Gastric Cancer in an Iranian Population |
title_fullStr | Interleukin-6 Genetic Variation and Susceptibility to Gastric Cancer in an Iranian Population |
title_full_unstemmed | Interleukin-6 Genetic Variation and Susceptibility to Gastric Cancer in an Iranian Population |
title_short | Interleukin-6 Genetic Variation and Susceptibility to Gastric Cancer in an Iranian Population |
title_sort | interleukin-6 genetic variation and susceptibility to gastric cancer in an iranian population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773787/ https://www.ncbi.nlm.nih.gov/pubmed/29172275 http://dx.doi.org/10.22034/APJCP.2017.18.11.3025 |
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