Cargando…

Oxymatrine inhibits non–small cell lung cancer via suppression of EGFR signaling pathway

Epidermal growth factor receptor (EGFR) plays a crucial role in human non–small cell lung cancer (NSCLC) tumorigenesis. In this study, oxymatrine was identified as an EGFR signaling pathway inhibitor in NSCLC. Oxymatrine inhibited anchorage‐dependent and independent growth of NSCLC cell lines but ha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Wei, Yu, Xinfang, Tan, Shiming, Liu, Wenbin, Zhou, Li, Liu, Haidan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773973/ https://www.ncbi.nlm.nih.gov/pubmed/29239135 http://dx.doi.org/10.1002/cam4.1269

Ejemplares similares

Deguelin suppresses non-small cell lung cancer by inhibiting EGFR signaling and promoting GSK3β/FBW7-mediated Mcl-1 destabilization
por: Gao, Feng, et al.
Publicado: (2020)

Inhibition of PC4 radiosensitizes non‐small cell lung cancer by transcriptionally suppressing XLF
por: Zhang, Tian, et al.
Publicado: (2018)

Clathrin‐mediated EGFR endocytosis as a potential therapeutic strategy for overcoming primary resistance of EGFR TKI in wild‐type EGFR non‐small cell lung cancer
por: Kim, Boyeon, et al.
Publicado: (2020)

Targeting YAP‐p62 signaling axis suppresses the EGFR‐TKI‐resistant lung adenocarcinoma
por: Park, Hee Sun, et al.
Publicado: (2021)

Targeting USP13‐mediated drug tolerance increases the efficacy of EGFR inhibition of mutant EGFR in non‐small cell lung cancer
por: Giron, Philippe, et al.
Publicado: (2021)

COX7A1 suppresses the viability of human non‐small cell lung cancer cells via regulating autophagy
por: Zhao, Lei, et al.
Publicado: (2019)

Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis
por: Liu, Wenbin, et al.
Publicado: (2019)

LIMD1‐AS1 suppressed non‐small cell lung cancer progression through stabilizing LIMD1 mRNA via hnRNP U
por: Pan, Jianyuan, et al.
Publicado: (2020)

Heterogeneity among tumors with acquired resistance to EGFR tyrosine kinase inhibitors harboring EGFR‐T790M mutation in non‐small cell lung cancer cells
por: Katayama, Yuki, et al.
Publicado: (2022)

lncRNA ABHD11‐AS1, regulated by the EGFR pathway, contributes to the ovarian cancer tumorigenesis by epigenetically suppressing TIMP2
por: Zeng, Xiang‐Yang, et al.
Publicado: (2019)

Metformin synergistic pemetrexed suppresses non‐small‐cell lung cancer cell proliferation and invasion in vitro
por: Zhang, Yan, et al.
Publicado: (2017)

Sputum cell‐free DNA: Valued surrogate sample for the detection of EGFR exon 20 p.T790M mutation in patients with advanced lung adenocarcinoma and acquired resistance to EGFR‐TKIs
por: Wang, Zheng, et al.
Publicado: (2021)

Screening common signaling pathways associated with drug resistance in non‐small cell lung cancer via gene expression profile analysis
por: Sun, Ting, et al.
Publicado: (2019)

Long noncoding RNA PART1 promotes progression of non‐small cell lung cancer cells via JAK‐STAT signaling pathway
por: Zhu, Dengyan, et al.
Publicado: (2019)

Licochalcone A inhibits EGFR signalling and translationally suppresses survivin expression in human cancer cells
por: Gao, Feng, et al.
Publicado: (2020)

Puerarin 6″‐O‐xyloside suppressed HCC via regulating proliferation, stemness, and apoptosis with inhibited PI3K/AKT/mTOR
por: Li, Long, et al.
Publicado: (2020)

Erlotinib induces the human non–small‐cell lung cancer cells apoptosis via activating ROS‐dependent JNK pathways
por: Shan, Fenglian, et al.
Publicado: (2016)

Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression
por: Jin, Yinshan, et al.
Publicado: (2020)

Dihydroartemisinin induces apoptosis and inhibits proliferation, migration, and invasion in epithelial ovarian cancer via inhibition of the hedgehog signaling pathway
por: Liu, Yanmei, et al.
Publicado: (2018)

MicroRNA‐4286 promotes cell proliferation, migration, and invasion via PTEN regulation of the PI3K/Akt pathway in non‐small cell lung cancer
por: Ling, Chunhua, et al.
Publicado: (2019)

Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer
por: Theard, Patricia L, et al.
Publicado: (2020)

Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway
por: Li, Ming, et al.
Publicado: (2017)

Knockdown of SP1/Syncytin1 axis inhibits the proliferation and metastasis through the AKT and ERK1/2 signaling pathways in non‐small cell lung cancer
por: Li, Xiaohui, et al.
Publicado: (2019)

Nonconserved miR‐608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase‐3 pathways by targeting the 3′‐UTRs of RAC2/BCL2L1 and the coding region of PAK4
por: Zhang, Xu, et al.
Publicado: (2019)

Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells
por: Yang, Yufei, et al.
Publicado: (2018)

Inhibition of prostate cancer growth by solanine requires the suppression of cell cycle proteins and the activation of ROS/P38 signaling pathway
por: Pan, Bin, et al.
Publicado: (2016)

MiR‐145 inhibits human colorectal cancer cell migration and invasion via PAK4‐dependent pathway
por: Sheng, Nengquan, et al.
Publicado: (2017)

Downregulation of KIAA1199 by miR‐486‐5p suppresses tumorigenesis in lung cancer
por: Wang, Anqi, et al.
Publicado: (2020)

EGFR enhances the stemness and progression of oral cancer through inhibiting autophagic degradation of SOX2
por: Lv, Xiao‐Xi, et al.
Publicado: (2019)

MiR‐362 suppresses cervical cancer progression via directly targeting BAP31 and activating TGFβ/Smad pathway
por: Yang, Shuya, et al.
Publicado: (2020)

MiR‐646 suppresses proliferation and metastasis of non‐small cell lung cancer by repressing FGF2 and CCND2
por: Wang, Jing, et al.
Publicado: (2020)

Embryonic stem cell microenvironment suppresses the malignancy of cutaneous melanoma cells by down‐regulating PI3K/AKT pathway
por: Wang, Chenjie, et al.
Publicado: (2019)

HHLA2 deficiency inhibits non‐small cell lung cancer progression and THP‐1 macrophage M2 polarization
por: Sun, Wenjie, et al.
Publicado: (2021)

DACH1 suppresses epithelial to mesenchymal transition (EMT) through Notch1 pathway and reverses progestin resistance in endometrial carcinoma
por: Zhou, Qing, et al.
Publicado: (2019)

miR‐541 suppresses proliferation and invasion of squamous cell lung carcinoma cell lines via directly targeting high‐mobility group AT‐hook 2
por: Xu, Li, et al.
Publicado: (2018)

MYST1/KAT8 contributes to tumor progression by activating EGFR signaling in glioblastoma cells
por: Dong, Zhen, et al.
Publicado: (2019)

YAP1 promotes multidrug resistance of small cell lung cancer by CD74‐related signaling pathways
por: Song, Yongchun, et al.
Publicado: (2019)

Oxymatrine exerts protective effects on osteoarthritis via modulating chondrocyte homoeostasis and suppressing osteoclastogenesis
por: Jiang, Yafei, et al.
Publicado: (2018)

Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy
por: Chen, Leying, et al.
Publicado: (2022)

Oxymatrine Inhibits the Proliferation and Invasion of Breast Cancer Cells via the PI3K Pathway
por: Guo, Lin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_7inidd6vnvvg2spf96i53lgkr7