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Ionic liquids for addressing unmet needs in healthcare

Advances in the field of ionic liquids have opened new applications beyond their traditional use as solvents into other fields especially healthcare. The broad chemical space, rich with structurally diverse ions, and coupled with the flexibility to form complementary ion pairs enables task‐specific...

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Detalles Bibliográficos
Autores principales: Agatemor, Christian, Ibsen, Kelly N., Tanner, Eden E. L., Mitragotri, Samir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773981/
https://www.ncbi.nlm.nih.gov/pubmed/29376130
http://dx.doi.org/10.1002/btm2.10083
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author Agatemor, Christian
Ibsen, Kelly N.
Tanner, Eden E. L.
Mitragotri, Samir
author_facet Agatemor, Christian
Ibsen, Kelly N.
Tanner, Eden E. L.
Mitragotri, Samir
author_sort Agatemor, Christian
collection PubMed
description Advances in the field of ionic liquids have opened new applications beyond their traditional use as solvents into other fields especially healthcare. The broad chemical space, rich with structurally diverse ions, and coupled with the flexibility to form complementary ion pairs enables task‐specific optimization at the molecular level to design ionic liquids for envisioned functions. Consequently, ionic liquids now are tailored as innovative solutions to address many problems in medicine. To date, ionic liquids have been designed to promote dissolution of poorly soluble drugs and disrupt physiological barriers to transport drugs to targeted sites. Also, their antimicrobial activity has been demonstrated and could be exploited to prevent and treat infectious diseases. Metal‐containing ionic liquids have also been designed and offer unique features due to incorporation of metals. Here, we review application‐driven investigations of ionic liquids in medicine with respect to current status and future potential.
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spelling pubmed-57739812018-01-26 Ionic liquids for addressing unmet needs in healthcare Agatemor, Christian Ibsen, Kelly N. Tanner, Eden E. L. Mitragotri, Samir Bioeng Transl Med Review Advances in the field of ionic liquids have opened new applications beyond their traditional use as solvents into other fields especially healthcare. The broad chemical space, rich with structurally diverse ions, and coupled with the flexibility to form complementary ion pairs enables task‐specific optimization at the molecular level to design ionic liquids for envisioned functions. Consequently, ionic liquids now are tailored as innovative solutions to address many problems in medicine. To date, ionic liquids have been designed to promote dissolution of poorly soluble drugs and disrupt physiological barriers to transport drugs to targeted sites. Also, their antimicrobial activity has been demonstrated and could be exploited to prevent and treat infectious diseases. Metal‐containing ionic liquids have also been designed and offer unique features due to incorporation of metals. Here, we review application‐driven investigations of ionic liquids in medicine with respect to current status and future potential. John Wiley and Sons Inc. 2018-01-19 /pmc/articles/PMC5773981/ /pubmed/29376130 http://dx.doi.org/10.1002/btm2.10083 Text en © 2017 The Authors. Bioengineering & Translational Medicine is published by Wiley Periodicals, Inc. on behalf of The American Institute of Chemical Engineers This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Agatemor, Christian
Ibsen, Kelly N.
Tanner, Eden E. L.
Mitragotri, Samir
Ionic liquids for addressing unmet needs in healthcare
title Ionic liquids for addressing unmet needs in healthcare
title_full Ionic liquids for addressing unmet needs in healthcare
title_fullStr Ionic liquids for addressing unmet needs in healthcare
title_full_unstemmed Ionic liquids for addressing unmet needs in healthcare
title_short Ionic liquids for addressing unmet needs in healthcare
title_sort ionic liquids for addressing unmet needs in healthcare
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773981/
https://www.ncbi.nlm.nih.gov/pubmed/29376130
http://dx.doi.org/10.1002/btm2.10083
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