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Ionic liquids for addressing unmet needs in healthcare
Advances in the field of ionic liquids have opened new applications beyond their traditional use as solvents into other fields especially healthcare. The broad chemical space, rich with structurally diverse ions, and coupled with the flexibility to form complementary ion pairs enables task‐specific...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773981/ https://www.ncbi.nlm.nih.gov/pubmed/29376130 http://dx.doi.org/10.1002/btm2.10083 |
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author | Agatemor, Christian Ibsen, Kelly N. Tanner, Eden E. L. Mitragotri, Samir |
author_facet | Agatemor, Christian Ibsen, Kelly N. Tanner, Eden E. L. Mitragotri, Samir |
author_sort | Agatemor, Christian |
collection | PubMed |
description | Advances in the field of ionic liquids have opened new applications beyond their traditional use as solvents into other fields especially healthcare. The broad chemical space, rich with structurally diverse ions, and coupled with the flexibility to form complementary ion pairs enables task‐specific optimization at the molecular level to design ionic liquids for envisioned functions. Consequently, ionic liquids now are tailored as innovative solutions to address many problems in medicine. To date, ionic liquids have been designed to promote dissolution of poorly soluble drugs and disrupt physiological barriers to transport drugs to targeted sites. Also, their antimicrobial activity has been demonstrated and could be exploited to prevent and treat infectious diseases. Metal‐containing ionic liquids have also been designed and offer unique features due to incorporation of metals. Here, we review application‐driven investigations of ionic liquids in medicine with respect to current status and future potential. |
format | Online Article Text |
id | pubmed-5773981 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57739812018-01-26 Ionic liquids for addressing unmet needs in healthcare Agatemor, Christian Ibsen, Kelly N. Tanner, Eden E. L. Mitragotri, Samir Bioeng Transl Med Review Advances in the field of ionic liquids have opened new applications beyond their traditional use as solvents into other fields especially healthcare. The broad chemical space, rich with structurally diverse ions, and coupled with the flexibility to form complementary ion pairs enables task‐specific optimization at the molecular level to design ionic liquids for envisioned functions. Consequently, ionic liquids now are tailored as innovative solutions to address many problems in medicine. To date, ionic liquids have been designed to promote dissolution of poorly soluble drugs and disrupt physiological barriers to transport drugs to targeted sites. Also, their antimicrobial activity has been demonstrated and could be exploited to prevent and treat infectious diseases. Metal‐containing ionic liquids have also been designed and offer unique features due to incorporation of metals. Here, we review application‐driven investigations of ionic liquids in medicine with respect to current status and future potential. John Wiley and Sons Inc. 2018-01-19 /pmc/articles/PMC5773981/ /pubmed/29376130 http://dx.doi.org/10.1002/btm2.10083 Text en © 2017 The Authors. Bioengineering & Translational Medicine is published by Wiley Periodicals, Inc. on behalf of The American Institute of Chemical Engineers This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Agatemor, Christian Ibsen, Kelly N. Tanner, Eden E. L. Mitragotri, Samir Ionic liquids for addressing unmet needs in healthcare |
title | Ionic liquids for addressing unmet needs in healthcare |
title_full | Ionic liquids for addressing unmet needs in healthcare |
title_fullStr | Ionic liquids for addressing unmet needs in healthcare |
title_full_unstemmed | Ionic liquids for addressing unmet needs in healthcare |
title_short | Ionic liquids for addressing unmet needs in healthcare |
title_sort | ionic liquids for addressing unmet needs in healthcare |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773981/ https://www.ncbi.nlm.nih.gov/pubmed/29376130 http://dx.doi.org/10.1002/btm2.10083 |
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