Structure–Activity Relationship Studies with Tetrahydroquinoline Analogs as EPAC Inhibitors

[Image: see text] EPAC proteins are therapeutic targets for the potential treatment of cardiac hypertrophy and cancer metastasis. Several laboratories use a tetrahydroquinoline analog, CE3F4, to dissect the role of EPAC1 in various disease states. Here, we report SAR studies with tetrahydroquinoline...

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Detalles Bibliográficos
Autores principales: Sonawane, Yogesh A., Zhu, Yingmin, Garrison, Jered C., Ezell, Edward L., Zahid, Muhammad, Cheng, Xiaodong, Natarajan, Amarnath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774307/
https://www.ncbi.nlm.nih.gov/pubmed/29375750
http://dx.doi.org/10.1021/acsmedchemlett.7b00358

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