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The relationship between cervical precancerous lesion galectin-3 and p27 protein expression and clinical prognosis

The relationship between galectin-3 and p27(kip1) protein expression levels in cervical precancerous lesions and clinical prognosis were studied. A total of 74 patients with cervical intraepithelial neoplasia [(CIN), 20 cases classified as stage I, 24 cases as stage II and 30 cases as stage III] wer...

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Detalles Bibliográficos
Autores principales: Ma, Jianting, Zhang, Xingguang, He, Gang, Yang, Chunlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774464/
https://www.ncbi.nlm.nih.gov/pubmed/29434847
http://dx.doi.org/10.3892/ol.2017.7503
Descripción
Sumario:The relationship between galectin-3 and p27(kip1) protein expression levels in cervical precancerous lesions and clinical prognosis were studied. A total of 74 patients with cervical intraepithelial neoplasia [(CIN), 20 cases classified as stage I, 24 cases as stage II and 30 cases as stage III] were enrolled in this study. Tissue galectin-3, p27(kip1), vascular endothelial growth factor (VEGF)-2 and cyclin D protein levels were detected via immunohistochemical staining and reverse transcription polymerase chain reaction (PCR). Follow-up median duration was 13.5 months and recurrence rate was determined. Galectin-3, VEGF-2, and cyclin D expression was elevated in patients with higher stage CIN, whereas p27(kip1) showed the opposite trend (p<0.05). During follow-up, there were 3 cases (15.0%) of recurrence in the CIN-I group, 5 cases (20.8%) in the CIN-II group and 9 cases (30.0%) in CIN-III the group. No significant difference in recurrence rate was noted among the groups (p>0.05). The upregulation of galectin-3 and downregulation of p27(kip1) in CIN tissues may be related to tumor progression. This phenomenon will require further verification.