Combination of betulinic acid with diazen-1-ium-1,2-diolate nitric oxide moiety donating a novel anticancer candidate

BACKGROUND: Betulinic acid (BA) is a complex lupane triterpenoid with unique antineoplastic activity. However, its antiproliferative activity is far from satisfaction. In order to improve its anticancer efficacy, betulinic acid was conjugated with a nitric oxide (NO)-releasing moiety to get a novel...

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Detalles Bibliográficos
Autores principales: Zhang, Laiyin, Hou, Shuangxing, Li, Bo, Pan, Jianjian, Jiang, Liping, Zhou, Guiying, Gu, Hong, Zhao, Caixing, Lu, Huiping, Ma, Fenfen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774489/
https://www.ncbi.nlm.nih.gov/pubmed/29391813
http://dx.doi.org/10.2147/OTT.S154412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774489/
https://www.ncbi.nlm.nih.gov/pubmed/29391813
http://dx.doi.org/10.2147/OTT.S154412

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