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Combination of betulinic acid with diazen-1-ium-1,2-diolate nitric oxide moiety donating a novel anticancer candidate

BACKGROUND: Betulinic acid (BA) is a complex lupane triterpenoid with unique antineoplastic activity. However, its antiproliferative activity is far from satisfaction. In order to improve its anticancer efficacy, betulinic acid was conjugated with a nitric oxide (NO)-releasing moiety to get a novel...

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Detalles Bibliográficos
Autores principales:	Zhang, Laiyin, Hou, Shuangxing, Li, Bo, Pan, Jianjian, Jiang, Liping, Zhou, Guiying, Gu, Hong, Zhao, Caixing, Lu, Huiping, Ma, Fenfen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774489/ https://www.ncbi.nlm.nih.gov/pubmed/29391813 http://dx.doi.org/10.2147/OTT.S154412

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