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Development and preliminary validation of a new screening questionnaire for identifying atopic children

BACKGROUND: Allergic diseases represent a frequent and increasing condition affecting children. A screening questionnaire allowing an easy identification of children with symptoms of allergic diseases may improve management and clinical outcome. The aim of this study was to develop and validate an e...

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Autores principales: Sacchetti, Marta, Baiardini, Ilaria, Chini, Loredana, Moschese, Viviana, Bruscolini, Alice, Lambiase, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774591/
https://www.ncbi.nlm.nih.gov/pubmed/29388629
http://dx.doi.org/10.2147/PHMT.S142271
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author Sacchetti, Marta
Baiardini, Ilaria
Chini, Loredana
Moschese, Viviana
Bruscolini, Alice
Lambiase, Alessandro
author_facet Sacchetti, Marta
Baiardini, Ilaria
Chini, Loredana
Moschese, Viviana
Bruscolini, Alice
Lambiase, Alessandro
author_sort Sacchetti, Marta
collection PubMed
description BACKGROUND: Allergic diseases represent a frequent and increasing condition affecting children. A screening questionnaire allowing an easy identification of children with symptoms of allergic diseases may improve management and clinical outcome. The aim of this study was to develop and validate an easy-to-use screening questionnaire to detect children requiring further allergological evaluations. METHODS: A 10-item questionnaire, evaluating the presence and the history of the most frequent allergic conditions affecting children, including allergic asthma, allergic rhinitis and conjunctivitis, food allergy, and atopic dermatitis, was developed and administered to 214 parents of children from 5 to 10 years of age (163 with allergic disease and 51 healthy, nonallergic children). Validation was performed by Pearson’s correlation between the clinical diagnosis and the responses to the questionnaire. Internal consistency was computed by Cronbach’s alpha correlation coefficient. Sensitivity and specificity of the novel questionnaire were assessed by the receiver operating characteristic (ROC) curve. RESULTS: Validation analysis of the new children atopy (ChAt) questionnaire showed good internal consistency with a Cronbach’s alpha of 0.757. Responses to the items evaluating the presence of individual allergic conditions significantly correlated with the clinical diagnosis (p<0.001). The ROC curve showed an area of 0.956 and identified a cutoff value >2 of the ChAt questionnaire total score for detection of allergy (sensitivity =0.92 and specificity =0.902). CONCLUSION: The novel ChAt questionnaire represents a simple tool able to detect the presence of all major allergic diseases in a pediatric population allowing an early identification of allergic multimorbidity and potentially facilitating clinical management.
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spelling pubmed-57745912018-01-31 Development and preliminary validation of a new screening questionnaire for identifying atopic children Sacchetti, Marta Baiardini, Ilaria Chini, Loredana Moschese, Viviana Bruscolini, Alice Lambiase, Alessandro Pediatric Health Med Ther Original Research BACKGROUND: Allergic diseases represent a frequent and increasing condition affecting children. A screening questionnaire allowing an easy identification of children with symptoms of allergic diseases may improve management and clinical outcome. The aim of this study was to develop and validate an easy-to-use screening questionnaire to detect children requiring further allergological evaluations. METHODS: A 10-item questionnaire, evaluating the presence and the history of the most frequent allergic conditions affecting children, including allergic asthma, allergic rhinitis and conjunctivitis, food allergy, and atopic dermatitis, was developed and administered to 214 parents of children from 5 to 10 years of age (163 with allergic disease and 51 healthy, nonallergic children). Validation was performed by Pearson’s correlation between the clinical diagnosis and the responses to the questionnaire. Internal consistency was computed by Cronbach’s alpha correlation coefficient. Sensitivity and specificity of the novel questionnaire were assessed by the receiver operating characteristic (ROC) curve. RESULTS: Validation analysis of the new children atopy (ChAt) questionnaire showed good internal consistency with a Cronbach’s alpha of 0.757. Responses to the items evaluating the presence of individual allergic conditions significantly correlated with the clinical diagnosis (p<0.001). The ROC curve showed an area of 0.956 and identified a cutoff value >2 of the ChAt questionnaire total score for detection of allergy (sensitivity =0.92 and specificity =0.902). CONCLUSION: The novel ChAt questionnaire represents a simple tool able to detect the presence of all major allergic diseases in a pediatric population allowing an early identification of allergic multimorbidity and potentially facilitating clinical management. Dove Medical Press 2017-09-21 /pmc/articles/PMC5774591/ /pubmed/29388629 http://dx.doi.org/10.2147/PHMT.S142271 Text en © 2017 Sacchetti et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Sacchetti, Marta
Baiardini, Ilaria
Chini, Loredana
Moschese, Viviana
Bruscolini, Alice
Lambiase, Alessandro
Development and preliminary validation of a new screening questionnaire for identifying atopic children
title Development and preliminary validation of a new screening questionnaire for identifying atopic children
title_full Development and preliminary validation of a new screening questionnaire for identifying atopic children
title_fullStr Development and preliminary validation of a new screening questionnaire for identifying atopic children
title_full_unstemmed Development and preliminary validation of a new screening questionnaire for identifying atopic children
title_short Development and preliminary validation of a new screening questionnaire for identifying atopic children
title_sort development and preliminary validation of a new screening questionnaire for identifying atopic children
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774591/
https://www.ncbi.nlm.nih.gov/pubmed/29388629
http://dx.doi.org/10.2147/PHMT.S142271
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