Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice

Vascular endothelial growth factor-A (VEGF-A) is the master regulator of angiogenesis, vascular permeability and growth. However, its role in mature blood vessels is still not well understood. To better understand the role of VEGF-A in the adult vasculature, we generated a VEGF-A knockdown mouse mod...

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Detalles Bibliográficos
Autores principales: Merentie, Mari, Rissanen, Riina, Lottonen-Raikaslehto, Line, Huusko, Jenni, Gurzeler, Erika, Turunen, Mikko P., Holappa, Lari, Mäkinen, Petri, Ylä-Herttuala, Seppo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774698/
https://www.ncbi.nlm.nih.gov/pubmed/29351307
http://dx.doi.org/10.1371/journal.pone.0190981

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