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Effects of diffusion time on non-Gaussian diffusion and intravoxel incoherent motion (IVIM) MRI parameters in breast cancer and hepatocellular carcinoma xenograft models

BACKGROUND: Perfusion-related intravoxel incoherent motion (IVIM) and non-Gaussian diffusion magnetic resonance (MR) parameters are becoming important biomarkers for differentiating malignant from benign tumors without contrast agents. However, diffusion-time dependence has rarely been investigated...

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Autores principales: Iima, Mami, Nobashi, Tomomi, Imai, Hirohiko, Koyasu, Sho, Saga, Tsuneo, Nakamoto, Yuji, Kataoka, Masako, Yamamoto, Akira, Matsuda, Tetsuya, Togashi, Kaori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774737/
https://www.ncbi.nlm.nih.gov/pubmed/29372076
http://dx.doi.org/10.1177/2058460117751565
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author Iima, Mami
Nobashi, Tomomi
Imai, Hirohiko
Koyasu, Sho
Saga, Tsuneo
Nakamoto, Yuji
Kataoka, Masako
Yamamoto, Akira
Matsuda, Tetsuya
Togashi, Kaori
author_facet Iima, Mami
Nobashi, Tomomi
Imai, Hirohiko
Koyasu, Sho
Saga, Tsuneo
Nakamoto, Yuji
Kataoka, Masako
Yamamoto, Akira
Matsuda, Tetsuya
Togashi, Kaori
author_sort Iima, Mami
collection PubMed
description BACKGROUND: Perfusion-related intravoxel incoherent motion (IVIM) and non-Gaussian diffusion magnetic resonance (MR) parameters are becoming important biomarkers for differentiating malignant from benign tumors without contrast agents. However, diffusion-time dependence has rarely been investigated in tumors. PURPOSE: To investigate the relationship between diffusion time and diffusion parameters in breast cancer and hepatocellular carcinoma xenograft mouse models. MATERIAL AND METHODS: Diffusion-weighted MR images (DWI) were obtained on a 7-T magnetic resonance imaging (MRI) scanner at two different diffusion times (9.6 ms and 27.6 ms) in human breast cancer (MDA-MB-231) and hepatocellular carcinoma (HepG2 and PLC/PRF/5) xenograft mouse models. Perfusion-related IVIM (fIVIM and D*) and non-Gaussian diffusion (ADC(0) and K) parameters were estimated. Parametric maps of diffusion changes with the diffusion times were generated using a synthetic apparent diffusion coefficient (sADC) obtained from b = 438 and 2584 s/mm(2). RESULTS: ADC(0) values significantly decreased when diffusion times were changed from 9.6 ms to 27.6 ms in MDA-MB-231, HepG2, and PLC/PRF/5 groups (P = 0.0163, 0.0351, and 0.0170, respectively). K values significantly increased in MDA-MB-231 and HepG2 groups (P < 0.0003 and = 0.0007, respectively); however, no significant difference was detected in the PLC/PRF/5 group. fIVIM values increased, although not significantly (P = 0.164–0.748). The maps of sADC changes showed that diffusion changes with the diffusion time were not homogeneous across tumor tissues. CONCLUSION: Diffusion MR parameters in both breast cancer and HCC xenograft models were found to be diffusion time-dependent. Our results show that diffusion time is an important parameter to consider when interpreting DWI data.
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spelling pubmed-57747372018-01-25 Effects of diffusion time on non-Gaussian diffusion and intravoxel incoherent motion (IVIM) MRI parameters in breast cancer and hepatocellular carcinoma xenograft models Iima, Mami Nobashi, Tomomi Imai, Hirohiko Koyasu, Sho Saga, Tsuneo Nakamoto, Yuji Kataoka, Masako Yamamoto, Akira Matsuda, Tetsuya Togashi, Kaori Acta Radiol Open Research BACKGROUND: Perfusion-related intravoxel incoherent motion (IVIM) and non-Gaussian diffusion magnetic resonance (MR) parameters are becoming important biomarkers for differentiating malignant from benign tumors without contrast agents. However, diffusion-time dependence has rarely been investigated in tumors. PURPOSE: To investigate the relationship between diffusion time and diffusion parameters in breast cancer and hepatocellular carcinoma xenograft mouse models. MATERIAL AND METHODS: Diffusion-weighted MR images (DWI) were obtained on a 7-T magnetic resonance imaging (MRI) scanner at two different diffusion times (9.6 ms and 27.6 ms) in human breast cancer (MDA-MB-231) and hepatocellular carcinoma (HepG2 and PLC/PRF/5) xenograft mouse models. Perfusion-related IVIM (fIVIM and D*) and non-Gaussian diffusion (ADC(0) and K) parameters were estimated. Parametric maps of diffusion changes with the diffusion times were generated using a synthetic apparent diffusion coefficient (sADC) obtained from b = 438 and 2584 s/mm(2). RESULTS: ADC(0) values significantly decreased when diffusion times were changed from 9.6 ms to 27.6 ms in MDA-MB-231, HepG2, and PLC/PRF/5 groups (P = 0.0163, 0.0351, and 0.0170, respectively). K values significantly increased in MDA-MB-231 and HepG2 groups (P < 0.0003 and = 0.0007, respectively); however, no significant difference was detected in the PLC/PRF/5 group. fIVIM values increased, although not significantly (P = 0.164–0.748). The maps of sADC changes showed that diffusion changes with the diffusion time were not homogeneous across tumor tissues. CONCLUSION: Diffusion MR parameters in both breast cancer and HCC xenograft models were found to be diffusion time-dependent. Our results show that diffusion time is an important parameter to consider when interpreting DWI data. SAGE Publications 2018-01-11 /pmc/articles/PMC5774737/ /pubmed/29372076 http://dx.doi.org/10.1177/2058460117751565 Text en © The Foundation Acta Radiologica 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research
Iima, Mami
Nobashi, Tomomi
Imai, Hirohiko
Koyasu, Sho
Saga, Tsuneo
Nakamoto, Yuji
Kataoka, Masako
Yamamoto, Akira
Matsuda, Tetsuya
Togashi, Kaori
Effects of diffusion time on non-Gaussian diffusion and intravoxel incoherent motion (IVIM) MRI parameters in breast cancer and hepatocellular carcinoma xenograft models
title Effects of diffusion time on non-Gaussian diffusion and intravoxel incoherent motion (IVIM) MRI parameters in breast cancer and hepatocellular carcinoma xenograft models
title_full Effects of diffusion time on non-Gaussian diffusion and intravoxel incoherent motion (IVIM) MRI parameters in breast cancer and hepatocellular carcinoma xenograft models
title_fullStr Effects of diffusion time on non-Gaussian diffusion and intravoxel incoherent motion (IVIM) MRI parameters in breast cancer and hepatocellular carcinoma xenograft models
title_full_unstemmed Effects of diffusion time on non-Gaussian diffusion and intravoxel incoherent motion (IVIM) MRI parameters in breast cancer and hepatocellular carcinoma xenograft models
title_short Effects of diffusion time on non-Gaussian diffusion and intravoxel incoherent motion (IVIM) MRI parameters in breast cancer and hepatocellular carcinoma xenograft models
title_sort effects of diffusion time on non-gaussian diffusion and intravoxel incoherent motion (ivim) mri parameters in breast cancer and hepatocellular carcinoma xenograft models
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774737/
https://www.ncbi.nlm.nih.gov/pubmed/29372076
http://dx.doi.org/10.1177/2058460117751565
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