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Arrhythmogenic drugs can amplify spatial heterogeneities in the electrical restitution in perfused guinea-pig heart: An evidence from assessments of monophasic action potential durations and JT intervals
Non-uniform shortening of the action potential duration (APD(90)) in different myocardial regions upon heart rate acceleration can set abnormal repolarization gradients and promote arrhythmia. This study examined whether spatial heterogeneities in APD(90) restitution can be amplified by drugs with c...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774816/ https://www.ncbi.nlm.nih.gov/pubmed/29352276 http://dx.doi.org/10.1371/journal.pone.0191514 |