Elucidating the mechanism of the considerable mechanical stiffening of DNA induced by the couple Zn(2+)/Calix[4]arene-1,3-O-diphosphorous acid

The couple Calix[4]arene-1,3-O-diphosphorous acid (C4diP) and zinc ions (Zn(2+)) acts as a synergistic DNA binder. Silicon NanoTweezer (SNT) measurements show an increase in the mechanical stiffness of DNA bundles by a factor of >150, at Zn(2+) to C4diP ratios above 8, as compared to Zinc alone w...

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Detalles Bibliográficos
Autores principales: Tauran, Yannick, Tarhan, Mehmet C., Mollet, Laurent, Gerves, Jean Baptiste, Kumemura, Momoko, Jalabert, Laurent, Lafitte, Nicolas, Byun, Ikjoo, Kim, Beomjoon, Fujita, Hiroyuki, Collard, Dominique, Perret, Florent, Desbrosses, Mickael, Leonard, Didier, Goutaudier, Christelle, Coleman, Anthony W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775194/
https://www.ncbi.nlm.nih.gov/pubmed/29352239
http://dx.doi.org/10.1038/s41598-018-19712-4

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