Endogenous Retrovirus 3 – History, Physiology, and Pathology

Endogenous viral elements (EVE) seem to be present in all eukaryotic genomes. The composition of EVE varies between different species. The endogenous retrovirus 3 (ERV3) is one of these elements that is present only in humans and other Catarrhini. Conservation of ERV3 in most of the investigated Cat...

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Autores principales: Bustamante Rivera, Yomara Y., Brütting, Christine, Schmidt, Caroline, Volkmer, Ines, Staege, Martin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775217/
https://www.ncbi.nlm.nih.gov/pubmed/29379485
http://dx.doi.org/10.3389/fmicb.2017.02691
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author Bustamante Rivera, Yomara Y.
Brütting, Christine
Schmidt, Caroline
Volkmer, Ines
Staege, Martin S.
author_facet Bustamante Rivera, Yomara Y.
Brütting, Christine
Schmidt, Caroline
Volkmer, Ines
Staege, Martin S.
author_sort Bustamante Rivera, Yomara Y.
collection PubMed
description Endogenous viral elements (EVE) seem to be present in all eukaryotic genomes. The composition of EVE varies between different species. The endogenous retrovirus 3 (ERV3) is one of these elements that is present only in humans and other Catarrhini. Conservation of ERV3 in most of the investigated Catarrhini and the expression pattern in normal tissues suggest a putative physiological role of ERV3. On the other hand, ERV3 has been implicated in the pathogenesis of auto-immunity and cancer. In the present review we summarize knowledge about this interesting EVE. We propose the model that expression of ERV3 (and probably other EVE loci) under pathological conditions might be part of a metazoan SOS response.
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spelling pubmed-57752172018-01-29 Endogenous Retrovirus 3 – History, Physiology, and Pathology Bustamante Rivera, Yomara Y. Brütting, Christine Schmidt, Caroline Volkmer, Ines Staege, Martin S. Front Microbiol Microbiology Endogenous viral elements (EVE) seem to be present in all eukaryotic genomes. The composition of EVE varies between different species. The endogenous retrovirus 3 (ERV3) is one of these elements that is present only in humans and other Catarrhini. Conservation of ERV3 in most of the investigated Catarrhini and the expression pattern in normal tissues suggest a putative physiological role of ERV3. On the other hand, ERV3 has been implicated in the pathogenesis of auto-immunity and cancer. In the present review we summarize knowledge about this interesting EVE. We propose the model that expression of ERV3 (and probably other EVE loci) under pathological conditions might be part of a metazoan SOS response. Frontiers Media S.A. 2018-01-15 /pmc/articles/PMC5775217/ /pubmed/29379485 http://dx.doi.org/10.3389/fmicb.2017.02691 Text en Copyright © 2018 Bustamante Rivera, Brütting, Schmidt, Volkmer and Staege. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Bustamante Rivera, Yomara Y.
Brütting, Christine
Schmidt, Caroline
Volkmer, Ines
Staege, Martin S.
Endogenous Retrovirus 3 – History, Physiology, and Pathology
title Endogenous Retrovirus 3 – History, Physiology, and Pathology
title_full Endogenous Retrovirus 3 – History, Physiology, and Pathology
title_fullStr Endogenous Retrovirus 3 – History, Physiology, and Pathology
title_full_unstemmed Endogenous Retrovirus 3 – History, Physiology, and Pathology
title_short Endogenous Retrovirus 3 – History, Physiology, and Pathology
title_sort endogenous retrovirus 3 – history, physiology, and pathology
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775217/
https://www.ncbi.nlm.nih.gov/pubmed/29379485
http://dx.doi.org/10.3389/fmicb.2017.02691
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