Family Aggregation of HTLV-1 Infection Associated with FAS -670A/G Polymorphism: A Case Report

Human T-lymphotropic virus 1 (HTLV-1) infection has been associated with ATL and inflammatory diseases but remains a neglected health problem. HTLV-1 associated diseases were originally described as sporadic entities, but family aggregations have been reported. Viral, genetic, immunological and beha...

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Detalles Bibliográficos
Autores principales: Vallinoto, Antonio C. R., Santana, Bárbara B., Queiroz, Maria A. F., da Silva, Andrea N. M. R., Cayres-Vallinoto, Izaura M. V., da Costa, Carlos A., de Sousa, Maisa S., Ishak, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775226/
https://www.ncbi.nlm.nih.gov/pubmed/29379480
http://dx.doi.org/10.3389/fmicb.2017.02685
Descripción
Sumario:Human T-lymphotropic virus 1 (HTLV-1) infection has been associated with ATL and inflammatory diseases but remains a neglected health problem. HTLV-1 associated diseases were originally described as sporadic entities, but family aggregations have been reported. Viral, genetic, immunological and behavioral factors were used to explain family clusters, but until now a clear explanation remains uncertain. In the present study we report, for the first time, a family cluster of diseased persons presenting the infection across three generations associated with FAS -670A/G polymorphism.

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