Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA

The ubiquitously expressed RNA-binding proteins Roquin-1 and Roquin-2 are essential for appropriate immune cell function and postnatal survival of mice. Roquin proteins repress target mRNAs by recognizing secondary structures in their 3′-UTRs and by inducing mRNA decay. However, it is unknown if oth...

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Detalles Bibliográficos
Autores principales: Rehage, Nina, Davydova, Elena, Conrad, Christine, Behrens, Gesine, Maiser, Andreas, Stehklein, Jenny E., Brenner, Sven, Klein, Juliane, Jeridi, Aicha, Hoffmann, Anne, Lee, Eunhae, Dianzani, Umberto, Willemsen, Rob, Feederle, Regina, Reiche, Kristin, Hackermüller, Jörg, Leonhardt, Heinrich, Sharma, Sonia, Niessing, Dierk, Heissmeyer, Vigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775257/
https://www.ncbi.nlm.nih.gov/pubmed/29352114
http://dx.doi.org/10.1038/s41467-017-02582-1

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