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High Antigen Dose Is Detrimental to Post-Exposure Vaccine Protection against Tuberculosis

Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis (TB), causes 1.8M deaths annually. The current vaccine, BCG, has failed to eradicate TB leaving 25% of the world’s population with latent Mtb infection (LTBI), and 5–10% of these people will reactivate and develop active TB. An ef...

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Detalles Bibliográficos
Autores principales:	Billeskov, Rolf, Lindenstrøm, Thomas, Woodworth, Joshua, Vilaplana, Cristina, Cardona, Pere-Joan, Cassidy, Joseph P., Mortensen, Rasmus, Agger, Else Marie, Andersen, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775287/ https://www.ncbi.nlm.nih.gov/pubmed/29379507 http://dx.doi.org/10.3389/fimmu.2017.01973

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