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Arginine and Polyamines Fate in Leishmania Infection

Leishmania is a protozoan parasite that alternates its life cycle between the sand fly and the mammalian host macrophages, involving several environmental changes. The parasite responds to these changes by promoting a rapid metabolic adaptation through cellular signaling modifications that lead to t...

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Autores principales: Muxel, Sandra M., Aoki, Juliana I., Fernandes, Juliane C. R., Laranjeira-Silva, Maria F., Zampieri, Ricardo A., Acuña, Stephanie M., Müller, Karl E., Vanderlinde, Rubia H., Floeter-Winter, Lucile M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775291/
https://www.ncbi.nlm.nih.gov/pubmed/29379478
http://dx.doi.org/10.3389/fmicb.2017.02682
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author Muxel, Sandra M.
Aoki, Juliana I.
Fernandes, Juliane C. R.
Laranjeira-Silva, Maria F.
Zampieri, Ricardo A.
Acuña, Stephanie M.
Müller, Karl E.
Vanderlinde, Rubia H.
Floeter-Winter, Lucile M.
author_facet Muxel, Sandra M.
Aoki, Juliana I.
Fernandes, Juliane C. R.
Laranjeira-Silva, Maria F.
Zampieri, Ricardo A.
Acuña, Stephanie M.
Müller, Karl E.
Vanderlinde, Rubia H.
Floeter-Winter, Lucile M.
author_sort Muxel, Sandra M.
collection PubMed
description Leishmania is a protozoan parasite that alternates its life cycle between the sand fly and the mammalian host macrophages, involving several environmental changes. The parasite responds to these changes by promoting a rapid metabolic adaptation through cellular signaling modifications that lead to transcriptional and post-transcriptional gene expression regulation and morphological modifications. Molecular approaches such as gene expression regulation, next-generation sequencing (NGS), microRNA (miRNA) expression profiling, in cell Western blot analyses and enzymatic activity profiling, have been used to characterize the infection of murine BALB/c and C57BL/6 macrophages, as well as the human monocytic cell-lineage THP-1, with Leishmania amazonensis wild type (La-WT) or arginase knockout (La-arg(-)). These models are being used to elucidate physiological roles of arginine and polyamines pathways and the importance of arginase for the establishment of the infection. In this review, we will describe the main aspects of Leishmania-host interaction, focusing on the arginine and polyamines pathways and pointing to possible targets to be used for prognosis and/or in the control of the infection. The parasite enzymes, arginase and nitric oxide synthase-like, have essential roles in the parasite survival and in the maintenance of infection. On the other hand, in mammalian macrophages, defense mechanisms are activated inducing alterations in the mRNA, miRNA and enzymatic profiles that lead to the control of infection. Furthermore, the genetic background of both parasite and host are also important to define the fate of infection.
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spelling pubmed-57752912018-01-29 Arginine and Polyamines Fate in Leishmania Infection Muxel, Sandra M. Aoki, Juliana I. Fernandes, Juliane C. R. Laranjeira-Silva, Maria F. Zampieri, Ricardo A. Acuña, Stephanie M. Müller, Karl E. Vanderlinde, Rubia H. Floeter-Winter, Lucile M. Front Microbiol Microbiology Leishmania is a protozoan parasite that alternates its life cycle between the sand fly and the mammalian host macrophages, involving several environmental changes. The parasite responds to these changes by promoting a rapid metabolic adaptation through cellular signaling modifications that lead to transcriptional and post-transcriptional gene expression regulation and morphological modifications. Molecular approaches such as gene expression regulation, next-generation sequencing (NGS), microRNA (miRNA) expression profiling, in cell Western blot analyses and enzymatic activity profiling, have been used to characterize the infection of murine BALB/c and C57BL/6 macrophages, as well as the human monocytic cell-lineage THP-1, with Leishmania amazonensis wild type (La-WT) or arginase knockout (La-arg(-)). These models are being used to elucidate physiological roles of arginine and polyamines pathways and the importance of arginase for the establishment of the infection. In this review, we will describe the main aspects of Leishmania-host interaction, focusing on the arginine and polyamines pathways and pointing to possible targets to be used for prognosis and/or in the control of the infection. The parasite enzymes, arginase and nitric oxide synthase-like, have essential roles in the parasite survival and in the maintenance of infection. On the other hand, in mammalian macrophages, defense mechanisms are activated inducing alterations in the mRNA, miRNA and enzymatic profiles that lead to the control of infection. Furthermore, the genetic background of both parasite and host are also important to define the fate of infection. Frontiers Media S.A. 2018-01-15 /pmc/articles/PMC5775291/ /pubmed/29379478 http://dx.doi.org/10.3389/fmicb.2017.02682 Text en Copyright © 2018 Muxel, Aoki, Fernandes, Laranjeira-Silva, Zampieri, Acuña, Müller, Vanderlinde and Floeter-Winter. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Muxel, Sandra M.
Aoki, Juliana I.
Fernandes, Juliane C. R.
Laranjeira-Silva, Maria F.
Zampieri, Ricardo A.
Acuña, Stephanie M.
Müller, Karl E.
Vanderlinde, Rubia H.
Floeter-Winter, Lucile M.
Arginine and Polyamines Fate in Leishmania Infection
title Arginine and Polyamines Fate in Leishmania Infection
title_full Arginine and Polyamines Fate in Leishmania Infection
title_fullStr Arginine and Polyamines Fate in Leishmania Infection
title_full_unstemmed Arginine and Polyamines Fate in Leishmania Infection
title_short Arginine and Polyamines Fate in Leishmania Infection
title_sort arginine and polyamines fate in leishmania infection
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775291/
https://www.ncbi.nlm.nih.gov/pubmed/29379478
http://dx.doi.org/10.3389/fmicb.2017.02682
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