Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing

Direct generation of skeletal muscle cells from human pluripotent stem cells (hPSCs) would be beneficial for drug testing, drug discovery, and disease modelling in vitro. Here we show a rapid and robust method to induce myogenic differentiation of hPSCs by introducing mRNA encoding MYOD1 together wi...

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Detalles Bibliográficos
Autores principales: Akiyama, Tomohiko, Sato, Saeko, Chikazawa-Nohtomi, Nana, Soma, Atsumi, Kimura, Hiromi, Wakabayashi, Shunichi, Ko, Shigeru B. H., Ko, Minoru S. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775307/
https://www.ncbi.nlm.nih.gov/pubmed/29352121
http://dx.doi.org/10.1038/s41598-017-19114-y

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