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Relationship between serum cortisol level and degree of false lumen thrombosis in patients with uncomplicated type B aortic dissection

Partial thrombosis of the false lumen in uncomplicated type B aortic dissection (uTBAD) is associated with an increased late mortality risk. Whether the serum cortisol level can affect false lumen thrombosis in patients with uTBAD has not been well characterized. This study was performed on 87 patie...

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Autores principales: Wu, Yani, Sun, Yudong, Wei, Xiaolong, Zhang, Lei, Han, Tonglei, Zhao, Zhiqing, Zhou, Jian, Jing, Zaiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775319/
https://www.ncbi.nlm.nih.gov/pubmed/29352180
http://dx.doi.org/10.1038/s41598-018-19691-6
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author Wu, Yani
Sun, Yudong
Wei, Xiaolong
Zhang, Lei
Han, Tonglei
Zhao, Zhiqing
Zhou, Jian
Jing, Zaiping
author_facet Wu, Yani
Sun, Yudong
Wei, Xiaolong
Zhang, Lei
Han, Tonglei
Zhao, Zhiqing
Zhou, Jian
Jing, Zaiping
author_sort Wu, Yani
collection PubMed
description Partial thrombosis of the false lumen in uncomplicated type B aortic dissection (uTBAD) is associated with an increased late mortality risk. Whether the serum cortisol level can affect false lumen thrombosis in patients with uTBAD has not been well characterized. This study was performed on 87 patients with uTBAD. A curve-fitting method was used to analyze the relationship between serum cortisol and partial thrombosis of false lumen. Univariate and multivariate logistic regression analyses were used to identify false lumen partial thrombosis–associated serum cortisol. Curve-fitting’s result revealed a characteristic U shape, and 14.0 µg/dL was considered as the cutoff point for serum cortisol. The results of univariate and multivariate logistic regression analyses suggested that when trisecting the serum cortisol level into three parts, the low and high levels of serum cortisol could significantly affect the occurrence of false lumen partial thrombosis compared with the middle level. The odds ratio value of the low and high levels of serum cortisol was 6.12 and 4.65, respectively, in the univariate analysis, and 24.32 and 3.93, respectively, in the multivariate analysis. Low or high levels of serum cortisol might influence the natural result of uTBAD through affecting the false lumen thrombosis.
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spelling pubmed-57753192018-01-26 Relationship between serum cortisol level and degree of false lumen thrombosis in patients with uncomplicated type B aortic dissection Wu, Yani Sun, Yudong Wei, Xiaolong Zhang, Lei Han, Tonglei Zhao, Zhiqing Zhou, Jian Jing, Zaiping Sci Rep Article Partial thrombosis of the false lumen in uncomplicated type B aortic dissection (uTBAD) is associated with an increased late mortality risk. Whether the serum cortisol level can affect false lumen thrombosis in patients with uTBAD has not been well characterized. This study was performed on 87 patients with uTBAD. A curve-fitting method was used to analyze the relationship between serum cortisol and partial thrombosis of false lumen. Univariate and multivariate logistic regression analyses were used to identify false lumen partial thrombosis–associated serum cortisol. Curve-fitting’s result revealed a characteristic U shape, and 14.0 µg/dL was considered as the cutoff point for serum cortisol. The results of univariate and multivariate logistic regression analyses suggested that when trisecting the serum cortisol level into three parts, the low and high levels of serum cortisol could significantly affect the occurrence of false lumen partial thrombosis compared with the middle level. The odds ratio value of the low and high levels of serum cortisol was 6.12 and 4.65, respectively, in the univariate analysis, and 24.32 and 3.93, respectively, in the multivariate analysis. Low or high levels of serum cortisol might influence the natural result of uTBAD through affecting the false lumen thrombosis. Nature Publishing Group UK 2018-01-19 /pmc/articles/PMC5775319/ /pubmed/29352180 http://dx.doi.org/10.1038/s41598-018-19691-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wu, Yani
Sun, Yudong
Wei, Xiaolong
Zhang, Lei
Han, Tonglei
Zhao, Zhiqing
Zhou, Jian
Jing, Zaiping
Relationship between serum cortisol level and degree of false lumen thrombosis in patients with uncomplicated type B aortic dissection
title Relationship between serum cortisol level and degree of false lumen thrombosis in patients with uncomplicated type B aortic dissection
title_full Relationship between serum cortisol level and degree of false lumen thrombosis in patients with uncomplicated type B aortic dissection
title_fullStr Relationship between serum cortisol level and degree of false lumen thrombosis in patients with uncomplicated type B aortic dissection
title_full_unstemmed Relationship between serum cortisol level and degree of false lumen thrombosis in patients with uncomplicated type B aortic dissection
title_short Relationship between serum cortisol level and degree of false lumen thrombosis in patients with uncomplicated type B aortic dissection
title_sort relationship between serum cortisol level and degree of false lumen thrombosis in patients with uncomplicated type b aortic dissection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775319/
https://www.ncbi.nlm.nih.gov/pubmed/29352180
http://dx.doi.org/10.1038/s41598-018-19691-6
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